Glyburide vs Glucovance in the Treatment of GDM

Glyburide vs Glucovance in the Treatment of Gestational Diabetes

A randomized comparison of glyburide to glucovance (metformin -glyburide) in the management of diabetes in pregnancy.

This study will be a randomized open label trial of glyburide compared to glucovance in the management of gestational diabetes. We hypothesize that glucovance will provide improved glycemic control and a lower failure rate with no increase in neonatal adverse outcomes. Sixty-seven patients will be randomized by computer to each arm of the study. Outcomes will be glycemic control, failure rate of the drug to achieve glycemic goals, and neonatal outcomes.

Inclusion Criteria:

• Gestational diabetes
• Pregnancy > 12 weeks gestation
• Ability to give consent

Exclusion Criteria:

• Inability to consent to the study
• Pre-existing diabetes
• Glucose-6-phosphate dehydrogenase (G6PD) deficiency
• Serum creatinine >1
• Liver disease
• Allergy to sulfa;
• Allergy to glyburide;
• Allergy to metformin;
• Fetal anomalies