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In this observational study patients with subarachnoid hemorrhage (SAH) will be screened for sleep apnea (SA) to investigate if SA is associated with impaired blood pressure control and worse clinical outcome early after SAH.
Patients admitted with non-traumatic SAH will be consented and screened for sleep apnea within 48 hours after hospital admission. Blood pressure and clinical outcome will be monitored throughout ICU treatment and hospital stay, respectively. Diagnosis of sleep apnea will be confirmed on follow-up 3-6 month after SAH by sleep apnea screening (portable cardiorespiratory monitoring and out-of-center polysomnography, respectively).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with Sleep Apnea | Patients with increased apnea-hypopnea-index (>5/h) |
| |
| Patients without Sleep Apnea | Patients with normal apnea-hypopnea-index (5/h and below) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Sleep Apnea Screening (Out of Center Polysomnography Device) | Device |
|
| Measure | Description | Time Frame |
|---|---|---|
| Time to blood pressure target | The time required to reach blood pressure target as defined by care provider. | Within 10 Days of hospital admission with subarachnoid hemorrhage |
| Medication needed to achieve blood pressure target | Blood pressure medication required to reach blood pressure target as defined by care provider. | Within 10 Days of hospital admission with subarachnoid hemorrhage |
| Measure | Description | Time Frame |
|---|---|---|
| Change in modified ranking scale (mRS) from baseline to discharge and follow-up visit, respectively. | Change in modified ranking scale at hospital discharge and at follow-up (3-6 month after SAH) will be assessed and compared between patients with and without sleep apnea. The change from baseline to discharge/follow-up will be compared between groups. | 3 to 6 Month after SAH |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of Sleep Apnea in Patients with Subarachnoid Hemorrhage | 6 Month after SAH |
Inclusion Criteria:
Exclusion Criteria:
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Patients with Subarachnoid Hemorrhage admitted to a University Hospital
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Sebastian Zaremba, MD | Contact | +49(0)228-287-16566 | sebastian.zaremba@ukb.uni-bonn.de | |
| Erdem Gueresir, MD, PhD | Contact | +49(0)228-287-16566 | erdem.gueresir@ukb.uni-bonn.de |
| Name | Affiliation | Role |
|---|---|---|
| Erdem Gueresir, MD, PhD | Vice Chair of Department of Neurosurgery | Principal Investigator |
| Sebastian Zaremba, MD | Physician | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Neurology and Department of Neurosurgery | Recruiting | Bonn | D-53105 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32926343 | Derived | Zaremba S, Albus L, Vatter H, Klockgether T, Guresir E. Poor blood pressure control following subarachnoid hemorrhage in patients with sleep apnea. Sleep Breath. 2021 Jun;25(2):777-785. doi: 10.1007/s11325-020-02184-0. Epub 2020 Sep 14. |
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| ID | Term |
|---|---|
| D013345 | Subarachnoid Hemorrhage |
| D012891 | Sleep Apnea Syndromes |
| ID | Term |
|---|---|
| D020300 | Intracranial Hemorrhages |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| Change in NIH stroke scale score (NIHSS) from admission to discharge and follow-up visit, respectively. | Neurological outcome measured as score in NIHSS at hospital discharge and at follow-up (3-6 month after SAH) will be assessed and compared between patients with and without sleep apnea. The change from baseline to discharge/follow-up will be compared between groups. | 3 to 6 Month after SAH |
| Barthel Index at discharge at follow-up visit, respectively. | Impairment of daily living (score in Barthel index) at discharge and at follow-up visit (3 to 6 month after SAH) will be assessed. The change from baseline to discharge/follow-up will be compared between groups. | 3 to 6 Month after SAH |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001049 | Apnea |
| D012120 | Respiration Disorders |
| D012140 | Respiratory Tract Diseases |
| D020919 | Sleep Disorders, Intrinsic |
| D020920 | Dyssomnias |
| D012893 | Sleep Wake Disorders |