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The aim of this study is the identification of complications in diabetes mellitus pediatric patients and to compare the clinical, anthropometric, and biochemical characteristics between children in the different types of diabetes mellitus.
Diabetes mellitus is characterized by hyperglycemia resulting from defects in insulin secretion and/or insulin resistance in target tissues. This study identify the influence of pathogenic factors on the evolution of diabetes mellitus and in the presence of chronic complications.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Type 1 diabetes mellitus | Sudden onset of symptoms and non-overweight/obese | ||
| Type 2 diabetes mellitus | Insidious onset of symptoms and overweight/obese | ||
| Type 1.5 diabetes mellitus | Overlap of type 1 and type2 diabetes mellitus clinical characteristics | ||
| Other types of diabetes mellitus | According American Diabetes Association criteria |
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| Measure | Description | Time Frame |
|---|---|---|
| Diabetic retinopathy | A microvascular complication determined by ophthalmological evaluation | year 3 |
| Peripheral diabetic neuropathy | A microvascular complication determined by neurological exam in either foot | year 5 |
| Nerve damage | A microvascular complication determined by nerve conduction study in either foot | year 5 |
| Microalbuminuria | A microvascular complication determined by urine albumin excretion >= 30 mg/day | annual |
| Cardiac function | A cardiovascular risk indicator determined by echocardiogram | year 5 |
| Cognitive evaluation | Determined by scores on the Mini-Mental State Examination | year 3 |
| Intelligence quotient evaluation | Determined by Intelligence quotient test | year 3 |
| Measure | Description | Time Frame |
|---|---|---|
| Body composition | Determined by body mass index (BMI) percentiles computed from physical measurements of height and weight and corresponding percentile tables | annual |
| Glycemic control | Determined by HbA1c |
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Inclusion Criteria:
Exclusion Criteria:
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Children and adolescents (boys and girls) from 1 months to 17 years of age that had recently been diagnosed with diabetes mellitus.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| María L Evia-Viscarra | Contact | +52 (477) 2672000 | 1405 | mlola.evia@hraeb.gob.mx |
| Name | Affiliation | Role |
|---|---|---|
| María L Evia-Viscarra | Department of Pediatric Endocrinology, Hospital Regional de Alta Especialidad del Bajío | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hospital Regional de Alta Especialidad del Bajío | Recruiting | León | Guanajuato | 37660 | Mexico |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27992493 | Derived | Evia-Viscarra ML, Guardado-Mendoza R, Rodea-Montero ER. Clinical and Metabolic Characteristics among Mexican Children with Different Types of Diabetes Mellitus. PLoS One. 2016 Dec 16;11(12):e0168377. doi: 10.1371/journal.pone.0168377. eCollection 2016. |
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| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
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| annual |
| Beta cell function | Determined by fasting C peptide | annual |
| Pancreatic autoimmunity | Determined by pancreas autoantibodies | onset of diabetes |
| Insulin resistance | Determined by insulin sensitivity | annual |
| Alpha cell function | Determined by glucagon | year 5 |
| Hyperlipidemia | Determined by lipid profile | annual |
| Hypothyroidism | Determined by thyroid profile | annual |
| Hypertension | Determined by collection of systolic and diastolic blood pressure and calculation of their percentile values | annual |