Efficacy of KCl Plus 0.9%NaCl Compare With KCl Plus 0.45%NaCl

Efficacy of KCl Plus 0.9%NaCl Compare With KCl Plus 0.45%NaCl for Correction of Hypokalemia in Hospitalized Patients

evaluate efficacy and safety of IV administration of potassium chloride (KCl) plus 0.9%NaCl compare with KCl plus half-strength normal saline solution (0.45%NaCl) in correcting hypokalemia

Hypokalemia is frequently encountered in hospitalized patients. Intravenous (IV) potassium repletion with saline is preferred used for initial therapy. However, administration of normal saline (0.9%NaCl) usually provokes sodium and potassium diuresis, thus, it might delay reversal of the hypokalemia.

Object of this study : to evaluate efficacy and safety of IV administration of potassium chloride (KCl) plus 0.9%NaCl compare with KCl plus half-strength normal saline solution (0.45%NaCl) in correcting hypokalemia.

Inclusion Criteria:

• Serum K+ 2.5-3.49 mmol/L
• No life threatening condition from hypokalemia

Exclusion Criteria:

• Pregnancy
• Volume overload, heart failure
• Hypotension
• Acute kidney injury
• Dysnatremia
• K+ shift
• Salt wasting nephropathy