Propofol Pharmacokinetics and Pharmacodynamics Modelling

Modelling Propofol Pharmacokinetics and Pharmacodynamics During an Intravenous Anaesthesia Guided by the Bispectral Index (BIS)

The main purpose of this research is to develop a population pharmacokinetic and pharmacodynamic model of Propofol when used for induction and maintenance of anaesthesia, using BIS as a pharmacodynamic endpoint.

A covariate analysis will be performed in order to account for variability in pharmacokinetic and pharmacodynamic parameters. The influence of age and obesity on propofol pharmacokinetic parameters will be particularly addressed.

Inclusion Criteria:

• Adult patients admitted for nose or ear surgery, bariatric surgery or urgent orthopaedic surgery.

Exclusion Criteria:

• Severe hepatic or renal insufficiency;
• Significant haemodynamic instability previous to the surgery;
• Allergy to eggs or propofol at the time of enrolment;
• Predictive criteria for difficult airway management.