Evaluation of Prolonged Apnea Supported by High Frequency Non-invasive Ventilation.

Evaluation of Prolonged Apnea Supported by High Frequency Non-invasive Ventilation.

The purpose of the study is to assess the efficacy of high-frequency non-invasive ventilation on apnea duration, carbon dioxide clearance and oxygen delivery in healthy subjets and patients with lung disease.

High frequency ventilation (HF-V) allows to ensure oxygen delivery and carbon dioxide clearance despite the absence of thoracic movement in anesthetized, invasively ventilated subjects. This same technique could be applied by a non-invasive interface (HF-NIV), allowing to obtain a prolonged apnea (absence of thoraco-abdominal respiratory movements) in awaken subjects. Such an application would be of interest for several clinical applications, e.g. lung imaging and radio-therapy treatment on lung cancer. The purpose of the study is to assess the effect of different HF-NIV setting on the apnea duration, carbon dioxide clearance and oxygen delivery in healthy subjets and patients with lung diseases.

Inclusion Criteria:

• healthy subjets : normal respiratory function and no known lung disease
• lung disease patients : chronic obstructive pulmonary disease, Sarcoidosis, Cystic fibrosis
• age >=18y

Exclusion Criteria:

• increased pneumothorax risk under positive pressure ventilation
• pregnancy