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| ID | Type | Description | Link |
|---|---|---|---|
| Narina Goulvaden | Other Identifier | Tianjin medical university |
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Different concentration of sevoflurane was given to maintain anesthesia. The dose of propofol to maintain BIS between 40-60 and the consumption of rocuronium was recorded and evaluated.
2 age group of patients was selected, 40-60 years and above 60 years. Maintenance of anesthesia was carried out using different concentration of Sevoflurane, ie MAC 0.5, 0.75 and 1.0. Bis value was kept between 40-60 and the dose of propofol required was recorded. Rocuronium infusion given in a close loop infusion system for different group was tabulated. The results was then analysed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SP1- sevoflurane MAC 0.5 | Experimental | In this group, patient of age 40-60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, Sevoflurane is started to achieve the desired MAC of 0.5. Propofol infusion is started to keep BIS between 40-60. |
|
| SP2- Sevoflurane MAC 0.75 | Experimental | In this group, patient of age 40-60 years, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen.Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, Sevoflurane is started to achieve the desired MAC of 0.75. Propofol infusion is started to keep BIS between 40-60. |
|
| SP3 -Sevoflurane MAC 1.0 | Experimental | In this group, patient of age 40-60 years, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, Sevoflurane is started to achieve the desired MAC of 1.0. Propofol infusion is started to keep BIS between 40-60. |
|
| SP4- Sevoflurane MAC 0.5 |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MAC 0.5 | Drug | 0.5 MAC Sevoflurane |
|
| Measure | Description | Time Frame |
|---|---|---|
| consumption of propofol | Propofol, Etomidate, Rocuronium consumption under specific concentration of sevoflurane keeping BIS between 40-60 | Intraoperative |
| Measure | Description | Time Frame |
|---|---|---|
| Recovery Index | T25%-T75% | Intraoperative |
| Onset time | Time from starting infusion of Rocuronium at induction till T<10% | Intraoperative |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Guolin Wang, Professor | Head of department anesthesiology | Principal Investigator |
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| ID | Term |
|---|---|
| D015742 | Propofol |
| D005045 | Etomidate |
| D000077123 | Rocuronium |
| ID | Term |
|---|---|
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
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| Experimental |
In this group, patient above 60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, sevoflurane is started to achieve the desired MAC of 0.5. Propofol infusion is started to keep BIS between 40-60. |
|
| SP5- Sevoflurane MAC 0.75 | Experimental | In this group, patient above 60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, Sevoflurane is started to achieve the desired MAC of 0.75. Propofol infusion is started to keep BIS between 40-60. |
|
| SE1- Sevoflurane MAC 0.5 | Experimental | In this group, patient of age 40-60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, sevoflurane is started to achieve the desired MAC of 0.5. Etomidate infusion is started to keep BIS between 40-60. |
|
| SE2- Sevoflurane 0.75 | Experimental | In this group, patient of age 40-60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, sevoflurane is started to achieve the desired MAC of 0.5. Etomidate infusion is started to keep BIS between 40-60. |
|
| SE3- Sevoflurane MAC 1.0 | Experimental | In this group, patient of age 40-60 years of age, ASA I/II, undergoing elective abdominal or gynecological surgery are chosen. Neuromuscular function prior to induction is assessed by acceleromyography by stimulation of ulnar nerve and noting the response of adductor pollicis. After induction and intubation, Sevoflurane is started to achieve the desired MAC of 0.5. Etomidate infusion is started to keep BIS between 40-60. |
|
| MAC 0.75 | Drug | 0.75 MAC Sevoflurane |
|
| MAC 1.0 | Drug | 1.0 MAC Sevoflurane |
|
| Propofol | Drug | Propofol consumption |
|
| Etomidate | Drug | Etomidate consumption |
|
| Rocuronium | Drug | Consumption of Rocuronium |
|
| Sevoflurane time | Time from starting sevoflurane till end tidal concentration is reached | Intraoperative |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D000732 | Androstanols |
| D000731 | Androstanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |