Rocuronium Consumption in Etomidate-based and Propofol-based General Anesthesia Under Sevoflurane

Consumption of Rocuronium Under Etomidate-based Versus Propofol-based Maintenance of General Anesthesia Under Different Concentration of Sevoflurane- BIS Guided Clinical Trial in a Closed Loop Infusion System

Different concentration of sevoflurane was given to maintain anesthesia. The dose of propofol to maintain BIS between 40-60 and the consumption of rocuronium was recorded and evaluated.

2 age group of patients was selected, 40-60 years and above 60 years. Maintenance of anesthesia was carried out using different concentration of Sevoflurane, ie MAC 0.5, 0.75 and 1.0. Bis value was kept between 40-60 and the dose of propofol required was recorded. Rocuronium infusion given in a close loop infusion system for different group was tabulated. The results was then analysed.

Inclusion Criteria:

• BMI < 30
• elective Gynaecological/abdominal/urological surgery
• Operation time < 3hrs
• ASA I/II
• Intubated patients

Exclusion Criteria:

• Coronary artery disease, cardiac, lung, hepatic and renal insufficiency
• Severe uncontrolled HBP
• Obesity (BMI >30)
• Neuromuscular and metabolic diseases
• Receiving medication known to influence neuromuscular transmission
• Pregnancy
• Psychiatric disorders
• Allergy history to any of the drugs that will be used