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| Name | Class |
|---|---|
| FONDATION POUR L'AIDE A LA RECHERCHE SUR LA SCLEROSE EN PLAQUES | UNKNOWN |
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In addition to the physical, cognitive and psychological symptoms experienced by individuals with Multiple Sclerosis (MS), there is new research which indicates that some individuals with MS have a deficit in emotional processing, specifically, facial affect recognition. Emotional processing is defined as "a central aspect of social cognition". Models of social cognition indicate that emotional processing is an essential component of interpersonal relationships. The failure to accurately perceive other's emotions has been shown to lead to difficulty in social relationships, misinterpreting other's affect, and consequently, inappropriate responding.
However, even though a significant number of individuals with MS have impairments in emotional processing, we do not yet have an understanding of how these impairments affect the social functioning of individuals with MS, including the impact of these deficits on family structure. It is well-known that MS impacts one's social functioning including factors such as employment, daily living activities and interpersonal relationships. Recently a strong correlation was observed between reduced social participation in MS and quality of life. There is evidence to suggest that emotional processing deficits lie at the heart of this reduced social participation in persons with MS, leading to decreased social functioning and thus reduced quality of life. However, to date, this hypothesis has not been tested.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| patient | Experimental | MS diagnosis according to McDonald criteria (Polman et al., 2005). Relapsing-remitting MS (RRMS) according to Lublin et al. (1996); |
|
| Control | Experimental | healthy subject |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Clinical evaluation | Other | • Clinical assessment : Expanded Disability Status Scale (EDSS), ambulation test. Medications will be recorded. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Interaction between measures of emotional processing (z score) and functional measures of social interaction | among the 3 groups (impaired MS, no impaired MS and HS) | At inclusion (day 0) |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation between measures of emotional processing with cognitive testing (z scores by domain) and cognitive functioning evaluated by significant other | (BAFQ) | At inclusion (day 0) |
| Correlation between measures of emotional processing and quality of life measures |
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Inclusion Criteria (patient group):
Inclusion Criteria (healthy control):
Exclusion Criteria (patient group):
Exclusion Criteria (healthy control):
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| Name | Affiliation | Role |
|---|---|---|
| Bruno BROCHET, Prof | University Hospital, Bordeaux | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de Bordeaux | Bordeaux | 33000 | France | |||
| CHU de Dijon |
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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| Cognitive evaluation | Other | • Neuropsychological, psychological, social and social cognitive evaluation |
|
(MUSIQoL questionnaire). |
| At inclusion (day 0) |
| Impact of the cognitive impairment on the relationship of emotional processing (z score) with interpersonal relationships (family, friendship, marital) and society integration and social functioning. | At inclusion (day 0) |
| Dijon |
| 21079 |
| France |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |