RAD 1501: A Trial of Virtual Cone Trigeminal Neuralgia Radiosurgery

RAD 1501: A Phase II Trial of Virtual Cone Trigeminal Neuralgia Radiosurgery

To determine the feasibility of frameless Virtual Cone trigeminal neuralgia radiosurgery at a single institution prior to multi-institutional enrollment.

To determine the feasibility of frameless Virtual Cone trigeminal neuralgia radiosurgery at a single institution prior to multi-institutional enrollment. To measure pain relief after Virtual Cone radiosurgery utilizing the Barrow Neurologic Institute Pain Intensity Score (BNI).

Inclusion Criteria:

• Patients with trigeminal neuralgia pain that is not well controlled despite medical management (BNI 4 OR BNI 5)
• Patients must have an ECOG status of 0, 1, or 2
• Patients must be at least 18 years of age
• Life expectancy must be greater than 12 months
• MRI of brain within prior 12 months to confirm lack of other causes of facial pain
• All patients must be given written informed consent

Exclusion Criteria:

• Patients who have had prior brain radiosurgery or therapeutic radiation therapy to the pons
• Patients with atypical trigeminal neuralgia or headache pain syndromes
• Patients with pain associated with multiple sclerosis or base of skull tumor
• Patients with medical contra-indications to MR imaging (e.g. pacemaker)