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Labor and delivery is a unique physiological experience of women. Inappropriate length of labor progress during vaginal delivery may produce great risks for mother and fetus. Especially the slow progress is one of the most important reasons for the occurrence of cesarean section during vaginal delivery, which still with a high incidence in recent years.Previous studies have found that there was a significant correlation between the genetic polymorphisms of β 2-adrenergic receptor (β2AR) and the duration of vaginal delivery.Therefore, the researchers intend to investigate the distribution of β2-adrenergic receptor (β2AR) genetic polymorphisms among Chinese parturient and observe the relationship between the genetic polymorphisms and labor process after labor analgesia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| β2AR Arg16Arg (AA group) | People with β2AR Arg16Arg genotype. |
| |
| β2AR Arg16Gly (AG group) | People with β2AR Arg16Gly genotype. |
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| β2AR Gly16Gly (GG group) | People with β2AR Gly16Gly genotype. |
| |
| β2AR Gln27Gln (CC group) | People with β2AR Gln16Gln genotype. |
| |
| β2AR Gln27Glu (CG group) | People with β2AR Gln27Glu genotype. |
| |
| β2AR Glu27Glu (GG group) | People with β2AR Glu27Glu genotype. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| β2AR polymorphism | Genetic |
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| Measure | Description | Time Frame |
|---|---|---|
| total labor process | time from the regular uterus contractions until completed childbirth, assessed up to about 24h | up to about 24h |
| duration of the first stage | time from the regular uterus contractions to full cervix dilation,assessed up to about 20h | up to about 20h |
| duration of the second stage | time from full cervix dilation to the complete childbirth, assessed up to about 2h | up to about 2h |
| Maternal visual analogue scale | At time of initiation of analgesia and hourly thereafter until 2 hours postpartum (approximately 10 hours) | At time of initiation of analgesia and hourly thereafter until 2 hours postpartum (approximately 10 hours) |
| Measure | Description | Time Frame |
|---|---|---|
| method of delivery | At time of placental delivery | At time of placental delivery |
| Maternal modified Bromage scale | At time of initiation of analgesia and hourly thereafter until 2 hours postpartum (approximately 10 hours) |
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Inclusion Criteria:
Exclusion Criteria:
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The parturient undergoing labor analgesia in our hospital. And the eligible parturient aged at 23-43, gestational age 35-42 weeks with an ASA grade I-II, who spontaneously choosing vaginal delivery mode with epidural analgesia.
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| At time of initiation of analgesia and hourly thereafter until 2 hours postpartum (approximately 10 hours) |
| Rescue boluses, n of rescue boluses, and the consumption of the ropivacaine/sufentanil mixture | At two hours postpartum | At two hours postpartum |
| Maternal satisfaction with analgesia | At two hours postpartum | At two hours postpartum |
| Use of oxytocin after analgesia | At twenty-four hours postpartum | At twenty-four hours postpartum |
| Neonatal Apgar scale | At the first and fifth minutes after baby was born | At the first and fifth minutes after baby was born |
| Maximal oxytocin dose | At twenty-four hours postpartum | At twenty-four hours postpartum |
| Maternal heart rate, respiratory rate, and blood pressure | At time of initiation of analgesia and hourly thereafter until 4 hours postpartum (approximately 12 hours) | At time of initiation of analgesia and hourly thereafter until 4 hours postpartum (approximately 12 hours) |
| Neonatal weight | At delivery | At delivery |