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Objective: To evaluate intraperitoneal (IP) lidocaine administration and intravenous (IV) lidocaine infusion for postoperative pain control after cesarean section.
Study design: prospective randomized, double-blind, placebo-controlled study. Patients and methods: Initially, 165 pregnant full-term females, indicated to be underwent elective cesarean delivery for various indications were randomized equally to either group C (control, IP and IV saline), group IP (intraperitoneal lidocaine administration), or group IV (intravenous lidocaine infusion).Five patients were excluded from each group for various reasons. The outcome measures were postoperative pain scoring, total pethidine consumption and the need for postoperative analgesia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo control group | Placebo Comparator | Saline was given both intraperitoneally and intravenously during caesarean section |
|
| Intraperitoneal instillation group | Active Comparator | Patients received 1.75 ml/kg of 0.2% lidocaine (3.5mg/kg) with parietal peritoneal closure with intravenous normal saline in a volume equivalent to that used in intravenous lidocaine group as placebo to ensure blinding. |
|
| Intravenous injection group | Active Comparator | Patients received 1.5mg/kg of intravenous 1% lidocaine as bolus dose at induction and 2mg/kg/hour as continuous infusion of intravenous lidocaine until one hour after surgery and 100 ml of saline intraperitoneally as placebo to ensure blinding |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Intravenous normal saline | Drug | Normal saline in a volume equivalent to that used in intravenous lidocaine group |
|
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative pain scoring (number) | First 24 hours postoperative |
| Measure | Description | Time Frame |
|---|---|---|
| The need for rescue postoperative analgesia. | First 24 hours postoperative | |
| Total pethidine consumption in 24 hours (mg) | First 24 hours postoperative | |
| The time to bowel sounds, hours |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D012965 | Sodium Chloride |
| D008012 | Lidocaine |
| ID | Term |
|---|---|
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
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|
| Intraperitoneal normal saline | Drug | Patients received 00 ml of saline intraperitoneally |
|
|
| Intraperitoneal Lidocaine | Drug | Patients received 1.75 ml/kg of 0.2% lidocaine (3.5mg/kg) with parietal peritoneal closure. |
|
|
| Intravenous Lidocaine | Drug | Patients received 1.5mg/kg of intravenous 1% lidocaine as bolus dose at induction and 2mg/kg/hour as continuous infusion of intravenous lidocaine until one hour after surgery. |
|
|
| First 3 days postoperative |
| The time to start regular diet, days | First 3 days postoperative |
| Duration of hospital stay , days | First 3 days postoperative |
| Any reported side effects | First 3 days postoperative |
| D017670 |
| Sodium Compounds |
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |