Multifactorial Approach Associated With Orlistat (Xenical) for 4 Years Weight Loss Maintenance in Obese Adults

Multifactorial Approach Associated With Orlistat (Xenical) for 4 Years Weight Loss Maintenance in Obese Patients

This study will evaluate the efficacy of a multifactorial approach associated with orlistat (Xenical) in weight loss maintenance during 4 years. The effect of orlistat in combination with diet, physical activity, and/or cognitive behavioral therapy will be monitored.

Inclusion Criteria:

• Body mass index (BMI) greater than or equal to (>/=) 30 kilograms per meter-squared (kg/m^2), or BMI >/= 28 kg/m^2 with risk factors of diabetes, hypertension, or hyperlipidemia, before weight loss
• Documented weight loss >/= 10% of initial body weight obtained with diet, with or without psychological therapy or orlistat

Exclusion Criteria:

• Pregnant or lactating females
• History or presence of significant medical disorders
• Active gastrointestinal disorders such as peptic ulcer disease or malabsorption syndromes
• Pancreatic disease: pancreatic enzyme deficiency, history or current presence of pancreatitis
• Clinically significant abnormal clinical chemistry or hematology results
• Excessive alcohol intake
• Smoking cessation within the previous 6 months
• History or presence of cancer
• Administration of medicines known to alter body weight
• History or presence of cancer