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To establish if, in patients with new diagnosis of left ventricular dilatation without documentation at the coronary artery angiography of significant coronary artery lesions, there is a damage of the coronary microcirculation at the IMR (index of microcirculatory resistance) assessment
The Authors will enroll at the moment of coronary artery angiography patients without history of ischemic heart disease and new diagnosis (at transthoracic echocardiography) of left ventricular dilation.
All patients will undergo coronary artery angiography. To be enrolled, it is necessary to have the absence of significant coronary artery stenosis (angiographic evaluation of the lesion >40%) in all the vessels (main and side branch).
The Authors will proceed to perform the evaluation of the index of microvascular resistance (IMR). The target vessel will be the left anterior descending artery.
An intracoronary pressure/temperature sensor-tipped guidewire will be used. Thermodilution curves will be obtained during maximal hyperemia. The IMR will be calculated from the ratio of the mean distal coronary pressure at maximal hyperemia to the inverse of mean hyperemic transit time.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| left ventricle dilatation | The subjects of the investigation will be patients with recent diagnosis of unknown left ventricle dilatation. These subjects received coronary artery angiography as exam suggested by guidelines to discriminate the cause of left ventricle dilatation. In subjects without documentation of coronary artery lesions, the Authors will assess the index of microvascular resistance. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| index of microvascular resistance | Procedure | Measurement of the index of microvascular resistance in the left anterior descending artery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Index of microcirculatory resistance | Measurement of IMR in the left anterior descending artery of patients with new diagnosis of left ventricular dilatation and no significant stenosis in epicardial coronary arteries | during coronary artery angiography |
| Measure | Description | Time Frame |
|---|---|---|
| cardiac death | occurrence of cardiac death at 1 year | 1-year |
| Measure | Description | Time Frame |
|---|---|---|
| all-cause death | occurrence of all-cause death at 1 year | 1-year |
| heart failure | occurrence of hospital admission for heart failure | 1-year |
Inclusion Criteria:
Exclusion Criteria:
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Patients undergoing coronary artery angiography for new diagnosis of left ventricular dilatation (dilatative cardiomyopathy)
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| Name | Affiliation | Role |
|---|---|---|
| Gianluca Campo, MD | Azienda Ospedaliera Universitaria di Ferrara | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital of Ferrara | Cona | Ferrara | 44124 | Italy |
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| ID | Term |
|---|---|
| D009202 | Cardiomyopathies |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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