Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Gastric conduit ischemia or anastomotic breakdown after esophagectomy with cervical esophagogastrostomy often cause severe complications, such as leakage, necrotic organs, and strictures. Thus, the purpose of this study is the safety and efficacy of endoscopic evaluation about reconstructive organs after esophagectomy. The investigators evaluate endoscopic predictions using classifications in acute phase after esophagogastrostomy.
Gastric conduit ischemia or anastomotic breakdown after esophagectomy with cervical esophagogastrostomy often cause severe complications, such as leakage, necrotic organs, and strictures. However the evaluation and prevention before developing gastric conduit ischemia have been established. The investigators have built a hypothesis that the evaluation for gastric mucosal ischemia in early phase after esophagectomy predict the complication of gastric conduit. Thus, the purpose of this study is the safety and efficacy of endoscopic evaluation about reconstructive organs after esophagectomy. The investigators evaluate endoscopic predictions using classifications in acute phase after esophagogastrostomy.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients after esophagectomy | Endoscopic examinations are performed at 1, 8, and 15 postoperative days. Endoscopic examination is added when abnormal findings are demonstrated. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Patients after esophagectomy | Procedure | postoperative endoscopic evaluation |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with endoscopy-related adverse events as assessed by Clavien-Dindo Classification | From 1 to 29 days after esophagectomy | |
| Number of participants with the classification of gastric conduit ischemia by endoscopic findings | From 1 to 15 days after esophagectomy | |
| Number of participants with the major complications of gastric conduit (strictures, leakage, necrosis) | From 1 to 29 days after esophagectomy |
| Measure | Description | Time Frame |
|---|---|---|
| Biological examination of the mucosal biopsy of gastric conduit as assessed by the ischemia related RNA copy number | From 1 to 29 days after esophagectomy | |
| Biological examination of the mucosal biopsy of gastric conduit as assessed by the scoring system for immunohistochemical staining |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Patients undergo an esophagectomy with reconstruction by a gastric pull-up for malignant or end-stage benign esophageal disease. The patients have a cervical esophagogastrostomy.
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Shinichiro Kobayashi | Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nagasaki University Hospital | Nagasaki | Nagasaki | 852-8501 | Japan |
Not provided
| Label | URL |
|---|---|
| Protocol information in University Hospital Medical Information Network (UMIN) (UMIN000019585) | View source |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D004938 | Esophageal Neoplasms |
| D003251 | Constriction, Pathologic |
| D057868 | Anastomotic Leak |
| D007511 | Ischemia |
| ID | Term |
|---|---|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
Not provided
Not provided
Not provided
Not provided
Not provided
dmp-DNA
The scoring system refer to the article entitled a scoring system for immunohistochemical staining: consensus report of the task force for basic research of the EORTC-GCCG. European Organization for Research and Treatment of Cancer-Gynaecological Cancer Cooperative Group (J Clin Pathol. 1997 Oct; 50(10): 801-804.)
| From 1 to 29 days after esophagectomy |
| Biological examination of gastric conduit as assessed by the Mitochondrial DNA copy number | From 1 to 29 days after esophagectomy |
| D006258 |
| Head and Neck Neoplasms |
| D004066 | Digestive System Diseases |
| D004935 | Esophageal Diseases |
| D005767 | Gastrointestinal Diseases |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D011183 | Postoperative Complications |
| D010335 | Pathologic Processes |