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| ID | Type | Description | Link |
|---|---|---|---|
| R01DA041071 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
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The purpose of this study is to assess the feasibility, acceptability and test the initial efficacy of eSBI, (electronic screening and brief intervention for alcohol use) coupled with STTR (Seek, Test, Treat, and Retain) in comparison to STTR only among YMSM (young men who have sex with men) and YTW (young transgender women) on frequency of substance use and engagement within the HIV (human immunodeficiency virus) and PrEP (pre-exposure prophylaxis) care continuum.
The purpose of this study is to assess the feasibility, acceptability and test the initial efficacy of eSBI, (electronic screening and brief intervention for alcohol use) coupled with STTR (Seek, Test, Treat, and Retain) in comparison to STTR only among YMSM (young men who have sex with men) and YTW (young transgender women) on frequency of substance use and engagement within the HIV and PrEP (pre-exposure prophylaxis) care continuum. We will do this with the following aims:
Aim 1: Assess the feasibility, acceptability and initial efficacy of electronic Screening & Brief Intervention + Seek, Test, Treat and Retain (eSBI+ STTR) compared to STTR-only to reduce alcohol and other substance use among 450 YMSM and YTW in Chicago, ages 16-25, at 1, 3, 6, and 12 months post-intervention.
Aim 2: To explore the initial efficacy of eSBI+STTR in comparison to STTR-only on secondary exploratory outcomes within the HIV and PrEP care continuum among YMSM and YTW.
Aim 3: Determine the degree to which sub-groups of youth are differentially impacted by eSBI+STTR based on socio-demographic characteristics and co-morbid mental health problems to inform future targeting and/or tailoring of the intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Alcohol Use BI | Experimental | Those who are randomized to the intervention will complete eSBI, an electronic brief intervention for substance use, which is comprised of 11 topical areas, each with a single webpage, in a motivational interviewing (MI) format. MI is a client-centered behavioral change approach. |
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| Nutrition Intervention | Active Comparator | Those randomized to the control will complete the attention control modules, a non-active brief time-matched attention control intervention of equal length (i.e., encouraging nutrition). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Alcohol Use BI | Behavioral | Those who are randomized to the intervention will complete eSBI, an electronic brief intervention for substance use, which is comprised of 11 topical areas, each with a single webpage, in a motivational interviewing (MI) format. MI is a client-centered behavioral change approach. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Frequency of Alcohol Use | Self-reported frequency of alcohol use in the previous 1 and 12 months assessed via computer-assisted self-interviewing. | 1, 3, 6 and 12 months post-intervention |
| Measure | Description | Time Frame |
|---|---|---|
| PrEP and HIV-related Care Engagement | PrEP and HIV-related medical care engagement (completed clinical visits) will be abstracted from medical records. | 1, 3, 6 and 12 months post-intervention |
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Inclusion Criteria:
Exclusion Criteria:
Male who has had sex with men OR transgender woman who has had sex with men (i.e., born male, identify as female/transgender, and at any point in the gender transition process)
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| Name | Affiliation | Role |
|---|---|---|
| Robert Garofalo, MD, MPH | Ann & Robert H Lurie Children's Hospital of Chicago | Principal Investigator |
| Niranjan Karnik, MD, PhD | Rush University Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ann & Robert H. Lurie Children's Hospital | Chicago | Illinois | 60611 | United States | ||
| Howard Brown Health Center |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36989027 | Derived | Karnik NS, Kuhns LM, Hotton AL, Del Vecchio N, McNulty M, Schneider J, Donenberg G, Keglovitz Baker K, Diskin R, Muldoon A, Rivera J, Summersett Williams F, Garofalo R. Findings From the Step Up, Test Up Study of an Electronic Screening and Brief Intervention for Alcohol Misuse in Adolescents and Young Adults Presenting for HIV Testing: Randomized Controlled Efficacy Trial. JMIR Ment Health. 2023 Mar 29;10:e43653. doi: 10.2196/43653. | |
| 31914971 | Derived |
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Share de-identified study data upon request to study contacts and with approval from the principal investigator(s).
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Post publication. Exact time frame undecided.
Share de-identified study data upon request to study contacts and with approval from the principal investigator(s).
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| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| ID | Term |
|---|---|
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D000431 | Ethanol |
| D004035 | Diet Therapy |
| ID | Term |
|---|---|
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D044623 | Nutrition Therapy |
| D013812 | Therapeutics |
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| Nutrition Intervention | Behavioral | Those randomized to the control will complete the attention control modules, a non-active brief time-matched attention control intervention of equal length (i.e., encouraging nutrition). |
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| Chicago |
| Illinois |
| 60613 |
| United States |
| University of Chicago | Chicago | Illinois | 60637 | United States |
| Kuhns LM, Karnik N, Hotton A, Muldoon A, Donenberg G, Keglovitz K, McNulty M, Schneider J, Summersett-Williams F, Garofalo R. A randomized controlled efficacy trial of an electronic screening and brief intervention for alcohol misuse in adolescents and young adults vulnerable to HIV infection: step up, test up study protocol. BMC Public Health. 2020 Jan 8;20(1):30. doi: 10.1186/s12889-020-8154-6. |