Observation Versus Immediate Surgery of Low Risk Bladder Cancer

Observation Versus Immediate Surgery of Low Risk Bladder Cancer

This trial is a randomized, multi-center, non-inferiority study comparing observation versus immediate surgery for low grade, noninvasive bladder cancer.

Inclusion Criteria:

• History of low grade, noninvasive urothelial carcinoma of the bladder with a new recurrence that meets the following criteria:
• total tumor burden ≤3cm in size (multiple lesions permitted)
• low grade appearance (grade 1 or grade 2)
• noninvasive appearance (Ta)
• no history of carcinoma in situ (CIS) or lesions concerning for CIS
• negative urine cytology (atypical or suspicious for low grade neoplasm are acceptable)

Exclusion Criteria:

• High grade and/or invasive and/or carcinoma in situ disease
• Concomitant upper tract urothelial carcinoma
• Any patient who is pregnant or who may have plans to become pregnant.
• Positive cytology