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The purpose of this study is to compare different combinations of cognitive training in retired professional football players and military veterans with a history of repeated concussions and persistent symptoms of impaired memory, concentration, attention, focus, or thinking.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Individual + Computer A | Active Comparator | Daily activities involve playing one hour of computer games (e.g., hangman, boggle, word scramble, chess; computer cognitive training A (CCA)), and two (2) 90 minute individual training sessions interacting one-on-one with a trainer in a variety of cognitive tasks including attention, memory, and comprehension of information. |
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| Individual + Computer B | Experimental | Daily activities involve playing an alternative set of computer games (computer cognitive training B (CCB)), and two (2) 90 minute individual training sessions interacting one-on-one with a trainer in a variety of cognitive tasks including attention, memory, and comprehension of information. |
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| Group + Computer B | Active Comparator | Daily activities involve group and individual cognitive therapy discussions on health, nutrition, and other topics and computer cognitive training B (CCB). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Psycho-Social Therapy | Behavioral |
| ||
| Cognitive Behavioral Computer Training |
| Measure | Description | Time Frame |
|---|---|---|
| Composite performance score based on battery of neuropsychological tests of working memory, learning, memory, and executive function. | Composite performance score on neuropsychological battery based on four primary domains : learning, memory, working memory, and executive function. | within one week following treatment completion |
| Participant reported outcomes | Measure of impact of program use on the patient's own view of their impairment and function. | within one week following treatment completion. |
| Working/school status | Measure of participants' employment status, and the number of hours worked/volunteered/in-school per week. | within one week following treatment completion. |
| Exercise-base assessments | Four sets of assessments that are closely modeled on study-related exercises in the auditory, visual, cognitive, and social-cognitive modules. These include auditory speed of processing, visual speed of processing, cognitive control speed of processing and face recognition, recall of unique faces, and emotional cue recognition. | within one week following treatment completion. |
| Functional assessments | Timed instrumental activities of daily living (TIADL) and the Mayo-Portland Adaptability Inventory (MPAI-4) for sensitive directly observed performance and well-accepted clinical impression measures. | within one week following treatment completion. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Robert W Van Boven, M.D., D.D.S. | Contact | 512-981-5801 | brainbodyhealthfoundation@gmail.com | |
| Mark R Taylor, Ph.D. | Contact | 586-945-6618 | mtaylormich@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Robert W Van Boven, M.D., D.D.S. | Brain & Body Health Foundation | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Brain & Body Health Institute, P.A. | Recruiting | Lakeway | Texas | 78734 | United States |
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| Device |
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| Interactive Trainer-Subject Sessions | Behavioral |
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| Active Control Games | Device |
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| ID | Term |
|---|---|
| D000070642 | Brain Injuries, Traumatic |
| D001924 | Brain Concussion |
| D019965 | Neurocognitive Disorders |
| ID | Term |
|---|---|
| D001930 | Brain Injuries |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D006259 | Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D014947 | Wounds and Injuries |
| D016489 | Head Injuries, Closed |
| D014949 | Wounds, Nonpenetrating |
| D001523 | Mental Disorders |
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