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| ID | Type | Description | Link |
|---|---|---|---|
| 2015-A01492-47 | Other Identifier | ANSM |
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| Name | Class |
|---|---|
| Hospices Civils de Lyon | OTHER |
| Centre Leon Berard | OTHER |
| Société Biophoton | UNKNOWN |
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The LLLT has an anti-inflammatory, analgesic effect and accelerates the healing of ulcerated lesions. There are little data in the literature showing its efficacy in prevention of mucositis in cohorts of patients with hematopoietic stem cells transplantation.
The main objective of this study is to assess the efficacy of a prophylactic low level laser therapy performed by nurses on the severity of oral mucositis during HSCT.
The main end point for efficacy is the reduction of severe mucositis (grade 3 or more). The secondary efficacy endpoints are the reduction of mucositis, whatever the grade, the reduction of time with mucositis, the time to onset of mucositis symptoms, the reduction of pain intensity and evaluation of quality of life.The secondary endpoints for safety are severe adverse events and potential toxicity. Patients will be allocated at inclusion with a 1/1 ratio either to laser-on or laser-off groups. In the laser group, patients will undergo laser therapy performed by nurses, which will consist of irradiation of the whole oral cavity during 2 minutes with 250mW power. In the laser-off group, laser therapy will be carried out with equipment off during the same time, and still performed by nurses. Protective eye shields will be used to avoid detrimental effects on eyes and to keep the subjects blind.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Laser treatment | Experimental | preventive treatment performed by nurses of mucositis by laser treating daily by scanning the entire oral cavity for 2 minutes with a power of 250 mW associated with mouthwashes several times a day (standard preventive treatment of mucositis) |
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| laser-off | Placebo Comparator | daily laser-off session performed by nurses associated with mouthwashes several times a day (standard preventive treatment of mucositis) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Laser treatment | Device | Patients randomized to the experimental arm receive in addition to mouthwash, preventive treatment of mucositis by LLLT performed by nurses consisting of daily scanning the entire oral cavity for 2 minutes with a power of 250 mW, starting with conditioning and ongoing until the onset of mucositis of grade 1. If the mucositis is localised, preventive laser will be kept on the healthy zones, and curative laser will be performed on painful zone. If the mucositis is general (more than 1 site), preventive laser is stopped for curative laser only. |
| Measure | Description | Time Frame |
|---|---|---|
| prevalence of grade 3 mucositis and more | prevalence of grade 3 and more mucositis following the classification proposed by WHO (world health organization) | 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| number of all grades of mucositis | The number of all grades of mucositis will be reported at day 30 post graft for all patients. | 30 days |
| duration of mucositis | The duration of mucositis will be reported at day 30 post graft for all patients. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Emmanuelle TAVERNIER, MD | Institut de Cancérologie Lucien Neuwirth | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre LĂ©on BĂ©rard | Lyon | 69373 | France | |||
| Centre Hospitalier Lyon Sud |
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| Placebo | Device | Patients randomized to the Placebo arm receive in addition to mouthwash fictive laser treatment performed by nurses until the onset of mucositis of grade 1. If the mucositis is localised, fictive laser will be kept on the healthy zones, and curative laser will be performed on painful zone. If the mucositis is general (more than 1 site), fictive laser is stopped for curative laser only. |
|
| 30 days |
| time of onset of mucositis | time of onset of mucositis will be assessed by measuring the interval between the beginning of packaging and the first day of mucositis has been assessed at a grade 1 | 30 days |
| Pain | Pain will be reported for each patient during their participation: 30 days post graft maximum. | 30 days |
| Quality of life | Quality of life will be reported for each patient during their participation: 30 days post graft maximum. | 30 days |
| Safety | serious adverse events will be reported for each patient during their participation: 30 days post graft maximum. | 30 days |
| Pierre-BĂ©nite |
| 69495 |
| France |
| Institut de Cancérologie Lucien Neuwirth | Saint-Priest-en-Jarez | 42271 | France |
| ID | Term |
|---|---|
| D019337 | Hematologic Neoplasms |
| D052016 | Mucositis |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D006402 | Hematologic Diseases |
| D006425 | Hemic and Lymphatic Diseases |
| D005759 | Gastroenteritis |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D053685 | Laser Therapy |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
| D055011 | Ablation Techniques |
| D013514 | Surgical Procedures, Operative |
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