Trial to Evaluate the Efficacy on Local Anesthesia and Safety of 2% Lidocaine HCl With Different Epinephrine Concentration in Patients Undergoing Surgical Extraction of Impacted Lower Third Molars

A Multi-center, Randomized, Double-blind, Crossover, phase4 Trial to Evaluate the Efficacy on Local Anesthesia and Safety of 2% Lidocaine HCl With Different Epinephrine Concentration in Patients Undergoing Surgical Extraction of Impacted Lower Third Molars

This study is Phase 4 trial which evaluates the safety and efficacy of 2% Lidocaine HCl with different epinephrine concentration in patients undergoing surgical extraction of impacted lower third molars

Inclusion Criteria:

• Age over 19
• Physical grade 1 or 2 by American Society of Anesthesiologists (ASA)
• Mesioangular or horizontal angulation categorized by winter classification

Exclusion Criteria:

• Allergy or hypersensitivity about the investigated products
• Any infection or edema during the extraction
• The following patients: clotting disorder, hyperthyroidism, arteriosclerosis, cardiac insufficiency, other cardiovascular disorders
• Pregnancy or breast-feeding
• Any conditions that the investigator considers not to appropriate for this study