Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| BG Trauma Center Ludwigshafen | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Goal of this study is to measure serum cholinesterase activity in patients with traumatic and/or burns injury admitted to the emergency room by using point-of- care-test system (POCT). Serum cholinesterase activity, measured using POCT system, might play an important role in the early diagnosis and prediction of patient outcome in trauma-induced systemic inflammation.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| polytrauma patients | Patients with severe traumatic injury, admitted to the emergency unit. Serum cholinesterase activity measurement using 10 µl whole blood, otherwise obtained through routine blood gas analysis upon arrival to the hospital. | ||
| burns patients | Patients with burns trauma, admitted to the emergency unit. Serum cholinesterase activity measurement using 10 µl whole blood, otherwise obtained through routine blood gas analysis upon arrival to the hospital. |
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| Early diagnosis of the systemic inflammation by using the serum cholinesterase activity measurement | By using Point-of-care measurement of serum cholinesterase activity (U/l) and by observing a change in the enzyme activity over time (reduction of serum cholinesterase activity within the first 6 hours after traumatic injury) would allow an additional tool in early diagnosis and treatment of systemic inflammation. | after completed patient recruitment, 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| correlation of the cholinesterase activity and the trauma/disease severity scores | To evaluate the correlation of the serum cholinesterase activity change with the trauma severity, the obtained serum cholinesterase activities (U/l) will be compared to the trauma severity scores (ISS, %TBSA). | after completed patient recruitment, 1 year |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Patients admitted to the emergency unit of the trauma and burns center
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Stefan Hofer, Prof. Dr. | University Hospital Heidelberg | Principal Investigator |
| Stefan Kleinschmidt, Prof. Dr. | Department of Anaesthesia, Intensive Care Medicine and Pain Therapy, BG Trauma Centre Ludwigshafen, Ludwigshafen, Germany | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anaesthesia, Intensive Care Medicine and Pain Therapy, BG Trauma Center Ludwigshafen | Ludwigshafen am Rhein | Rhineland-Palatinate | 67071 | Germany |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D014947 | Wounds and Injuries |
| D002056 | Burns |
| C537417 | Butyrylcholinesterase deficiency |
| D009104 | Multiple Trauma |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
A miniature amount (10 μl) of whole blood is needed for the serum cholinesterase activity analysis. This blood specimen will be taken from otherwise routine blood gas analysis collection, taken upon arrival into the emergency room, as a part of the standardized ICU diagnostic and therapeutic procedure. The serum cholinesterase activity analysis, therefore, doesn't require additional blood collection.