Not provided
Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| Grant Agreement n. 634869 | Other Grant/Funding Number | European Commission-Horizon 2020 |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Ben-Gurion University of the Negev | OTHER |
| Erasmus Medical Center | OTHER |
| Medical University of Graz | OTHER |
| Servicio Madrileño de Salud, Madrid, Spain |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The SCOPE study is an observational, multicenter, prospective cohort study aimed at evaluating a 2-year screening programme for CKD in a population of older patients, aged 75 years or more, in seven European Countries, in an attempt to investigate whether and to which extent currently available screening methods may identify older people at risk of worsening kidney function.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Subjects aged 75 years or older |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| blood sample collection | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Rate of estimated Glomerular Filtration Rate (eGFR) decline | eGFR will be calculated using the Berlin Initiative Study 1 (BIS1) equation | 24 months |
| Incidence of End Stage Renal Disease (ESRD) | ESRD will be defined as eGFR<15 mL/min/1.73 m2 or dialysis | 24 months |
| Measure | Description | Time Frame |
|---|---|---|
| Biomarkers of kidney function | cystatin C, beta2-microglobulin, beta-trace protein | Baseline and 24 months |
| Genetic and epigenetic analyses | circulating microRNA, telomere length in circulating leukocytes, DNA methylation, analysis of the whole genome |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
subjects with 75 years or older
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| MEDIZINISCHE UNIVERSITAT- Internal Medicine/Nephrology/Geriatric Department | Graz | 8036 | Austria | |||
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 38416398 | Derived | Freiberger E, Fabbietti P, Corsonello A, Lattanzio F, Sieber C, Tap L, Mattace-Raso F, Arnlov J, Carlsson AC, Roller-Wirnsberger R, Wirnsberger G, Moreno-Gonzalez R, Formiga F, Martinez SL, Gil P, Kostka T, Guligowska A, Yehoshua I, Melzer I, Kob R; SCOPE investigators. Short physical performance battery is not associated with falls and injurious falls in older persons: longitudinal data of the SCOPE project. Eur Geriatr Med. 2024 Jun;15(3):831-842. doi: 10.1007/s41999-024-00941-y. Epub 2024 Feb 28. | |
| 35999522 |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D051436 | Renal Insufficiency, Chronic |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
Not provided
Not provided
| OTHER |
| Institut Catala de Salut | OTHER_GOV |
| UNIVERSYTET MEDYCZNY W LODZI | UNKNOWN |
| Friedrich-Alexander-Universität Erlangen-Nürnberg | OTHER |
| Uppsala University | OTHER |
Not provided
Not provided
Not provided
plasma, serum, whole blood
| Baseline and 24 months |
| Incidence of CKD complications | anemia, hyperphosphatemia, acidosis, hypoalbuminemia, hyperparathyroidism, hyperkaliemia | 24 months |
| Incidence of major comorbidities | myocardial infarction, hospitalization for unstable angina, transient ischemic attack/stroke, heart failure events, interventional cardiology events, peripheral vascular intervention, and stent thrombosis | 24 months |
| Cardiovascular mortality | death resulting from acute myocardial infarction, sudden cardiac death, heart failure, stroke, CV procedures, CV hemorrhage, and other CV causes | 24 months |
| Comprehensive geriatric assessment (CGA) | Cognitive function (Mini Mental State Examination), depression (Geriatric Depression Scale), functional assessment (Basic Activity of Daily Living, Lawton Instrumental Activities of Daily Living Scale), health status (Cumulative Illness Rating Scale for Geriatrics), risk of malnutrition (Mini Nutritional Assessment), dietary intake assessment (24-h Dietary Recall), history of falls and incident falls, vision and hearing impairment, socioeconomic Status, physical Performance (Short Physical Performance Battery Test), muscle strength (Hand Grip Strength), quality of life (Euro-Qol 5D) | Baseline and 24 months |
| Healthcare resource consumption | previous physician visits, use of care services, hospital admissions, laboratory tests performed | Baseline and 24 months |
| FRIEDRICH-ALEXANDER-UNIVERSITAT-Institute for Biomedicine of Aging |
| Erlangen |
| 91054 |
| Germany |
| BEN-GURION UNIVERSITY-Geriatrics Department | Beersheba | 84105 | Israel |
| INRCA Research Hospital | Ancona | 60131 | Italy |
| INRCA Research Hospital | Cosenza | Italy |
| ERASMUS UNIVERSITAIR MEDISCH CENTRUM-Department of Internal Medicine | Rotterdam | 3015CE | Netherlands |
| UNIVERSYTET MEDYCZNY-Department of Geriatrics | Lodz | 90419 | Poland |
| INSTITUT CATALA DE LA SALUT-Internal Medicine Deparment | Barcelona | 08007 | Spain |
| SERVICIO MADRILENO DE SALUD-Geriatric Department | Madrid | 28020 | Spain |
| Derived |
| Freiberger E, Fabbietti P, Corsonello A, Lattanzio F, Artzi-Medvedik R, Kob R, Melzer I; SCOPE consortium; Britting S. Transient versus stable nature of fear of falling over 24 months in community-older persons with falls- data of the EU SCOPE project on Kidney function. BMC Geriatr. 2022 Aug 23;22(1):698. doi: 10.1186/s12877-022-03357-0. |
| 33008359 | Derived | Tap L, Corsonello A, Formiga F, Moreno-Gonzalez R, Arnlov J, Carlsson AC, Roller-Wirnsberger R, Wirnsberger G, Ziere G, Freiberger E, Sieber C, Kostka T, Guligowska A, Gil P, Martinez SL, Artzi-Medvedik R, Yehoshua I, Fabbietti P, Lattanzio F, Mattace-Raso F; SCOPE investigators. Is kidney function associated with cognition and mood in late life? : The Screening for CKD among Older People across Europe (SCOPE) study. BMC Geriatr. 2020 Oct 2;20(Suppl 1):297. doi: 10.1186/s12877-020-01707-4. |
| 33008307 | Derived | Britting S, Artzi-Medvedik R, Fabbietti P, Tap L, Mattace-Raso F, Corsonello A, Lattanzio F, Arnlov J, Carlsson AC, Roller-Wirnsberger R, Wirnsberger G, Kostka T, Guligowska A, Formiga F, Moreno-Gonzalez R, Gil P, Martinez SL, Kob R, Melzer I, Freiberger E; SCOPE investigators. Kidney function and other factors and their association with falls : The screening for CKD among older people across Europe (SCOPE) study. BMC Geriatr. 2020 Oct 2;20(Suppl 1):320. doi: 10.1186/s12877-020-01698-2. |
| 33008303 | Derived | Corsonello A, Fabbietti P, Formiga F, Moreno-Gonzalez R, Tap L, Mattace-Raso F, Roller-Wirnsberger R, Wirnsberger G, Arnlov J, Carlsson AC, Weingart C, Freiberger E, Kostka T, Guligowska A, Gil P, Martinez SL, Melzer I, Yehoshua I, Lattanzio F; SCOPE investigators. Chronic kidney disease in the context of multimorbidity patterns: the role of physical performance : The screening for CKD among older people across Europe (SCOPE) study. BMC Geriatr. 2020 Oct 2;20(Suppl 1):350. doi: 10.1186/s12877-020-01696-4. |
| 30309342 | Derived | Corsonello A, Tap L, Roller-Wirnsberger R, Wirnsberger G, Zoccali C, Kostka T, Guligowska A, Mattace-Raso F, Gil P, Fuentes LG, Meltzer I, Yehoshua I, Formiga-Perez F, Moreno-Gonzalez R, Weingart C, Freiberger E, Arnlov J, Carlsson AC, Bustacchini S, Lattanzio F; SCOPE investigators. Design and methodology of the screening for CKD among older patients across Europe (SCOPE) study: a multicenter cohort observational study. BMC Nephrol. 2018 Oct 11;19(1):260. doi: 10.1186/s12882-018-1030-2. |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |