Comparison of Cervical Cancer Screening Tests in HIV-infected Women in Lusaka, Zambia

Z 1313 - Comparison of Point-of-care Molecular Tests and Visual Inspection With Acetic Acid for Cervical Cancer Screening in HIV-infected Women in Lusaka, Zambia

This study will compare the test performance characteristics of visual inspection with acetic acid (VIA), Xpert HPV, and OncoE6 in HIV-infected women, to inform the possible inclusion of these molecular tests in future cervical cancer screening

This is a cross-sectional study taking place at cervical cancer prevention clinics in Lusaka, Zambia to determine the test performance characteristics (sensitivity, specificity, positive predictive value, and negative predictive value) of (1) visual inspection with acetic acid, (2) Xpert HPV, and (3) OncoE6 for the detection of CIN2+ among HIV-infected women. All cervical screening tests will be evaluated against a gold standard of histopathology obtained from cervical biopsies.

Inclusion Criteria:

• Women 18 years and older.
• Women with documented HIV-infection in their medical record or by on-site testing through voluntary counseling and testing.
• Women willing to undergo pelvic examination and cervical cancer screening.
• Women willing to provide written, informed consent.

Exclusion Criteria:

• Pregnancy