Additive Hemostatic Efficacy of EndoClot After EMR or ESD in the Gastrointestinal Tract

Italian Multicenter Prospective Randomized Trial to Compare Additive Hemostatic Efficacy of EndoClot System to Prevent Bleeding After Endoscopic Mucosal Resection or Endoscopic Submucosal Dissection of Lesions in the Gastrointestinal Tract

The investigators want to verify in a randomised trial, the effectiveness of EndoClotTM in preventing post-procedural bleeding after EMR (Endoscopic Mucosal Resection) or ESD (Endoscopic Submucosal Dissection) for sessile lesions >20 mm in the right colon

Inclusion Criteria:

• >18 years old
• lesions suitable for EMR or ESD
• > 20 mm
• site in the right colon

Exclusion Criteria:

• Severe cardiovascular pathologies
• Liver and Urinary dysfunctions
• Hematologic diseases
• Pregnancy and breast feeding
• impossible follow-up
• platelet and coagulation disorders (PLT < 50 x 109/L, INR > 2)
• Sensitivity or allergy to the drug