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The purpose of this Phase I/II study is to evaluate the safety and efficacy of dendritic cells(DC) vaccine combined with cytokine-induced killer (CIK) cells in patients with Advanced Non-Small-Cell Lung Cancer with bone metastases. Experimental DC was transfected Ad5 vector coding mRNAs including suppressor of cytokine signaling (SOCS) 1, MUC1 and Survivin,are used for DC-based immunotherapy. Based on the results of our previously preclinical study with DC vaccine combined with CIK cells, the investigators plan to perform the clinical trial.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| genetically modified dendritic cells + cytokine-induced killer | Biological | This Phase I/II Study to evaluate clinical efficacy, safety of genetically modified dendritic cells in combination with cytokine-induced killer cell treament in NSCLC with bone metastases. |
| Measure | Description | Time Frame |
|---|---|---|
| objective response rate (CR+PR) as measured by RECIST criteria | one month after DC/CIK treatment |
| Measure | Description | Time Frame |
|---|---|---|
| number of participants with adverse events | 3 days during DC/CIK treatment] |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Guo liang ding, master | Contact | dingguoliang1999@sina.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Affiliated Hospital to Academy of Military Medical Sciences | Beijing | Beijing Municipality | 100071 | China |
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