Perioperative Copeptin: Predictive Value and Risk Stratification in Patients Undergoing Major Surgery

Perioperative Copeptin: Predictive Value and Risk Stratification in Patients Undergoing Major Surgery

Observational cohort study examining the perioperative course of copeptin in patients undergoing elevated-risk surgery.

Inclusion Criteria:

• Adults >18 years
• Type of surgery for patients 1 to 30: abdominal aortic aneurysm repair, suprainguinal and infrainguinal vascular surgery, carotid surgery
• Type of surgery for patients 31 to 500: surgeries with elevated risks in general (as specified by 2014 ESC/ESA Guidelines on non-cardiac surgery:

cardiovascular assessment and management [Kristensen])

Exclusion Criteria:

• acute coronary Syndrome (ACS) at presentation (clinical assessment or documentation)
• Congestive heart failure at presentation (clinical assessment or documentation)
• Documented severe aortic stenosis (valve area <1cm2)
• Kidney dysfunction (clearance <50ml/min)
• Reduced left ventricular ejection fraction (LVEF) (<40%); if no LVEF is available, it will be assumed to be >40%
• Cancelled surgery
• Unwilling or unable to provide consent
• Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant