Effect of a Lipidic and Proteic Controlled Diet on Parkinson's Disease

Effect of a Lipidic and Proteic Controlled Diet on Resting Energy Expenditure, Body Composition and Symptoms in Patients With Parkinson's Disease

Parkinson's disease concerns some defects in carbohydrates metabolism involved in the progress of the pathology. Ketogenic diet has been largely studied as treatment on drug-resistant epilepsy and other neurologic diseases, but there is little information on the impact of this kind of diet in clinical aspects of Parkinson's disease. The aim of our study is thus to evaluate the effect of a lipid and protein controlled diet on resting energy expenditure, body composition and symptoms in patients with Parkinson's disease.

Parkinson's disease concerns some defects in carbohydrates metabolism involved in the progress of the pathology. Ketogenic diet has been largely studied as treatment on drug-resistant epilepsy and other neurologic diseases, but there is little information on the impact of this kind of diet in clinical aspects of Parkinson's disease. The aim of our study is thus to evaluate the effect of a lipid and protein controlled diet on resting energy expenditure, body composition and symptoms in Parkinson's disease patients.

Inclusion Criteria:

• patients with a diagnosis of Parkinson's disease, treated with L-Dopa or other dopaminergic drugs.
• Mini Mental State Examination (MMSE) >24.
• Activities of Daily Living >3.

Exclusion Criteria:

• Mini nutritional assessment <17; BMI <18, hypoalbuminemia or lymphopenia.
• acute or chronic liver diseases;
• renal function impairment (Clearance creatinine <30ml/min);
• cancer;
• acute inflammatory diseases;
• thyroid diseases;
• diabetes mellitus;
• dysphagia;
• dementia;
• dyslipidemia;
• history of recent cardiovascular or cerebrovascular events;
• psychiatric diseases;
• iatrogen parkinsonism.