Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis

Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis Without Acquired Immune Deficiency Syndrome

The main purpose of this study is to observe the clinical effect of intrathecal administration of liposomal amphotericin B in Cryptococcal Meningitis without Acquired Immune Deficiency Syndrome (AIDS).

Inclusion Criteria:

• Cryptococcus neoformans are found in CSF

Exclusion Criteria:

• Patients with serious heart, lung, liver and renal insufficiency.
• Patients who took broad-spectrum antibiotics and corticosteroids for a long-term.
• Patients with AIDS or obvious immunodeficiency.
• Patients with long term dialysis or intravenous catheter.
• Patients with other brain organic disease such as purulent meningitis, intracranial swelling, etc.