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Study suspended due to lack of PI to handle it
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| Name | Class |
|---|---|
| URC-CIC Paris Descartes Necker Cochin | OTHER |
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Rheumatoid arthritis (RA) is associated with a higher prevalence of infections, malignancies, osteoporotic fractures and cardiovascular diseases. Few data are available regarding the prevalence and severity of these comorbidities in elderly RA patients. The purpose of this study is to determine the effect of age on prevalence and severity of comorbidities in RA.
Prevalence of rheumatoid arthritis (RA) in elderly is increasing because of the increasing life expectancy. RA is associated with a higher prevalence of infections, malignancies, osteoporotic fractures and cardiovascular diseases. The purpose of this study is to determine the effect of age on prevalence and severity of comorbidities in RA. This study also aims to determine whether age influences disease progression and efficacy and tolerance of treatments.
This study will compare two groups of patients : patients older than 65 years old and patients younger than 50 years old, matched for gender and disease duration.
The first part of the study will be cross-sectional and will aim to compare characteristics regarding RA manifestations and comorbidities of the two groups at inclusion.
Whereas the second part will be prospective to assess the occurrence of comorbidities and the efficacy and safety of treatments in these two groups. Patients will be assessed every year during 5 years in accordance with usual follow-up of the patients.
This study could help to better manage elderly RA patients and to modify clinical practice.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Rheumatoid arthritis >65 years old | |||
| Rheumatoid arthritis <50 years old |
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| Measure | Description | Time Frame |
|---|---|---|
| Number of severe infections | Occurrence of severe infection requiring hospitalization or varicella-zoster virus | 5 years |
| Number of cancers | Occurrence of solid cancer or hemopathy | 5 years |
| Number of cardiovascular diseases | Occurrence of myocardial infarction or stroke | 5 years |
| Number of osteoporotic fractures | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| Disease Activity Score (DAS 28) | to evaluate articular activity | 5 years |
| Simple Disease Activity Index (SDAI) | to evaluate clinical articular activity of rheumatoid arthritis |
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Inclusion Criteria:
Exclusion Criteria:
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Rheumatoid arthritis patients from department A and B of rheumatology in Cochin hospital
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| Name | Affiliation | Role |
|---|---|---|
| Yannick ALLANORE, MD, PhD | Assistance Publique- Hôpitaux de Paris, Cochin Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cochin hospital | Paris | Paris | 75014 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24105334 | Background | Soubrier M, Tatar Z, Couderc M, Mathieu S, Dubost JJ. Rheumatoid arthritis in the elderly in the era of tight control. Drugs Aging. 2013 Nov;30(11):863-9. doi: 10.1007/s40266-013-0122-8. | |
| 22833532 | Background | Widdifield J, Bernatsky S, Paterson JM, Gunraj N, Thorne JC, Pope J, Cividino A, Bombardier C. Serious infections in a population-based cohort of 86,039 seniors with rheumatoid arthritis. Arthritis Care Res (Hoboken). 2013 Mar;65(3):353-61. doi: 10.1002/acr.21812. |
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| ID | Term |
|---|---|
| D001172 | Arthritis, Rheumatoid |
| D007239 | Infections |
| D010024 | Osteoporosis |
| D009369 | Neoplasms |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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| 5 years |
| Erythrocyte sedimentation rate | to evaluate biological articular activity of rheumatoid arthritis | 5 years |
| Measure of C-reactive protein (CRP) | to evaluate biological articular activity of rheumatoid arthritis | 5 years |
| Number of synovitis and/or tenosynovitis at ultrasound of hands | to evaluate articular activity of rheumatoid arthritis at ultrasound | 5 years |
| Health assessment questionnaire (HAQ) score | 5 years |
| Need of orthopaedic surgery | to evaluate severity of rheumatoid arthritis | 5 years |
| Number of erosions at X-rays (hands and feet) | to evaluate severity of rheumatoid arthritis | 5 years |
| Number of diabetes, arterial hypertension and dyslipidaemia | to evaluate risks factor of cardiovascular disease | 5 years |
| Number of cataracts | 5 years |
| Number of vaccinations | Previous influenza vaccination within the previous year and pneumococcal vaccination within the previous 5 years will be searched during medical interview. | 5 years |
| D003240 |
| Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D001851 | Bone Diseases, Metabolic |
| D001847 | Bone Diseases |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |