Potential Benefit of the Combination of Metamizole and Ibuprofen After Third Lower Molar Extraction

Potential Benefit of the Combination of Metamizole and Ibuprofen After Third Lower Molar Extraction

Postoperative pain is common and particularly outpatients may experience unsatisfactory pain relief. This randomized, double-blind, crossover study of postoperative pain in outpatients undergoing split-mouth, third lower molar extraction aims to examine whether or not the combination of metamizole and ibuprofen is superior to either drug alone.

Inclusion Criteria:

• planned sequential both-sided lower third molar extraction (split-mouth) with osteotomy (with or without upper molar extraction in local anesthesia)
• able to understand the study and the NRS scale

Exclusion Criteria:

• simultaneous both sided extraction or only upper third molar extraction
• general anesthesia
• known or presumed abnormal coagulation status
• known or presumed liver or renal dysfunction
• contraindication against metamizole known or suspected (known or suspected allergy against novalgin or other pyrazolones, anaphylactic reaction against NSAIDS, decreased bone marrow function or hematopoesis, hepatic porphyria, glucose-6-phosphate dehydrogenase deficiency, and pregnancy/breastfeeding)
• contraindication against ibuprofen (known or suspected allergy against ibuprofen, anaphylactic reaction against Nonsteroidal anti-inflammatory drugs (NSAID), active or recurrent stomach or duodenal ulcera or bleeding, severe liver or renal insufficiency, inflammatory bowel syndrome, and pregnancy/breastfeeding)
• pregnancy and breast feeding mothers