A Study of Avelumab With Axitinib Versus Sunitinib In Advanced Renal Cell Cancer (JAVELIN Renal 101) | NCT02684006 | Trialant

A Study of Avelumab With Axitinib Versus Sunitinib In Advanced Renal Cell Cancer (JAVELIN Renal 101) | NCT02684006 | Trialant

Ages Eligible for Study: Adult (18-64)Older Adult (65+)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Eligibility Criteria: Inclusion Criteria:

Histologically or cytologically confirmed advanced or metastatic RCC with clear cell component

Availability of a formalin-fixed, paraffin-embedded (FFPE) tumor tissue block from a de novo tumor biopsy during screening (biopsied tumor lesion should not be a RECIST target lesion). Alternatively, a recently obtained archival FFPE tumor tissue block (not cut slides) from a primary or metastatic tumor resection or biopsy can be provided if the following criteria are met: 1) the biopsy or resection was performed within 1 year of randomization AND 2) the patient has not received any intervening systemic anti-cancer treatment from the time the tissue was obtained and randomization onto the current study. If an FFPE tissue block cannot be provided as per documented regulations then, 15 unstained slides (10 minimum) will be acceptable

Availability of an archival FFPE tumor tissue from primary tumor resection specimen (if not provided per above). If an FFPE tissue block cannot be provided as per documented regulations 15 unstained slides (10 minimum) will be acceptable

At least one measurable lesion as defined by RECIST version 1.1 that has not been previously irradiated

Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1

Adequate bone marrow function, renal and liver functions

Exclusion Criteria:

Prior systemic therapy directed at advanced or metastatic RCC

Prior adjuvant or neoadjuvant therapy for RCC if disease progression or relapse has occurred during or within 12 months after the last dose of treatment.

Prior immunotherapy with IL-2, IFN-α, or anti PD 1, anti PD L1, anti PD L2, anti CD137, or anti cytotoxic T lymphocyte associated antigen 4 (CTLA 4) antibody (including ipilimumab), or any other antibody or drug specifically targeting T cell co stimulation or immune checkpoint pathways

Prior therapy with axitinib and/or sunitinib as well as any prior therapies with other VEGF pathway inhibitors

Newly diagnosed or active brain metastasis

Known severe hypersensitivity reactions to monoclonal antibodies (Grade ≥3), any history of anaphylaxis, or uncontrolled asthma (ie, 3 or more features of partially controlled asthma Global Initiative for Asthma 2011)

Any of the following in the previous 12 months: myocardial infarction, severe/unstable angina, coronary/peripheral artery bypass graft, symptomatic congestive heart failure, LVEF less than LLN, clinically significant pericardial effusion, cerebrovascular accident, transient ischemic attack

Any of the following in the previous 6 months: deep vein thrombosis or symptomatic pulmonary embolism

Vaccination within 4 weeks of the first dose of avelumab and while on trial is prohibited except for administration of inactivated vaccines (for example, inactivated influenza vaccines)

Southern Cancer Center

Daphne, Alabama 36526, United States

Southern Cancer Center

Mobile, Alabama 36607, United States

Southern Cancer Center

Mobile, Alabama 36608, United States

Tower Hematology Oncology Medical Group

Beverly Hills, California 90211, United States

City of Hope National Medical Center

Duarte, California 91010, United States

City of Hope

Duarte, California 91010, United States

Keck Hospital of USC

Los Angeles, California 90033, United States

Los Angeles General Medical Center

Los Angeles, California 90033, United States

USC IDS Pharmacy

Los Angeles, California 90033, United States

USC/Norris Comprehensive Cancer Center

Los Angeles, California 90033, United States

Cedars-Sinai Advanced Health Sciences Pavilion

Los Angeles, California 90048, United States

Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute

Los Angeles, California 90048, United States

Cedars-Sinai

Los Angeles, California 90048, United States

Rocky Mountain Cancer Centers

Aurora, Colorado 80012, United States

University of Colorado Cancer Center Anschutz Cancer Pavilion

Aurora, Colorado 80045, United States

University of Colorado Hospital - Clinical Trials Office (CTO)

Aurora, Colorado 80045, United States

University of Colorado Hospital

Aurora, Colorado 80045, United States

Rocky Mountain Cancer Centers

Colorado Springs, Colorado 80907, United States

Georgetown University Medical Center

Washington D.C., District of Columbia 20007, United States

Moffitt Cancer Center and Research Institute

Tampa, Florida 33612, United States

Emory University Hospital

Atlanta, Georgia 30322, United States

Investigational Drug Service- Emory University

Atlanta, Georgia 30322, United States

The Emory Clinic

Atlanta, Georgia 30322, United States

Winship Cancer Institute, Emory University

Atlanta, Georgia 30322, United States

East Jefferson General Hospital

Metairie, Louisiana 70006, United States

East Jefferson Hematology-Oncology Metairie Physician Service Inc.

Metairie, Louisiana 70006, United States

New England Cancer Specialists

Kennebunk, Maine 04043, United States

New England Cancer Specialists

Scarborough, Maine 04074, United States

New England Cancer Specialists

Topsham, Maine 04086, United States

Oncology Investigational Drug Services- The Sidney Kimmel Cancer Center at Johns Hopkins Hospital

Baltimore, Maryland 21231, United States

Johns Hopkins Hospital

Baltimore, Maryland 21287, United States

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Baltimore, Maryland 21287, United States

Massachusetts General Hospital (MGH)

Boston, Massachusetts 02114, United States

Massachusetts General Hospital Clinical Trials Pharmacy

Boston, Massachusetts 02114, United States

Brigham & Women's Hospital

Boston, Massachusetts 02115, United States

Beth Israel Deaconess Medical Center (BIDMC)

Boston, Massachusetts 02215, United States

Beth Israel Deaconess Medical Center Pharmacy - BIDMC

Boston, Massachusetts 02215, United States

Dana - Farber Cancer Institute

Boston, Massachusetts 02215, United States

Dana-Farber Cancer Institute

Boston, Massachusetts 02215, United States

Baystate Franklin Medical Center

Greenfield, Massachusetts 01301, United States

Mayo Clinic

Rochester, Minnesota 55905, United States

Barnes-Jewish Hospital, Siteman Cancer Center - St. Peters

City of Saint Peters, Missouri 63376, United States

Barnes-Jewish Hospital, Siteman Cancer Center - West County

Creve Coeur, Missouri 63141, United States

Barnes-Jewish Hospital, Siteman Cancer Center

St Louis, Missouri 63110, United States

Washington University Infusion Center Pharmacy

St Louis, Missouri 63110, United States

Washington University School of Medicine

St Louis, Missouri 63110, United States

Barnes-Jewish Hospital, Siteman Cancer Center - South County

St Louis, Missouri 63129, United States

St. Vincent Healthcare

Billings, Montana 59101, United States

Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana

Billings, Montana 59102, United States

Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada 75063, United States

Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada 89148, United States

Comprehensive Cancer Centers of Nevada

Las Vegas, Nevada 89169, United States

New York Oncology Hematology, P.C.

Albany, New York 12206, United States

New York Oncology Hematology, PC

Albany, New York 12208, United States

New York Oncology Hematology, P.C.

Clifton Park, New York 12065, United States

Memorial Sloan Kettering Cancer Center - Investigational Drug Service Pharmacy

Long Island City, New York 11101, United States

Laura & Isaac Perlmutter Cancer Center at NYU Langone

New York, New York 10016, United States

NYU Investigational Pharmacy

New York, New York 10016, United States

NYU Langone Medical Center

New York, New York 10016, United States

MSKCC-Monitoring Suite

New York, New York 10017, United States

Evelyn H. Lauder Breast and Imaging Center

New York, New York 10065, United States

Memorial Sloan Kettering Cancer Center

New York, New York 10065, United States

Sidney Kimmel Center for Prostate and Urologic Cancers

New York, New York 10065, United States

Stony Brook University-Cancer Center

Stony Brook, New York 11794, United States

Stony Brook University

Stony Brook, New York 11794, United States

Novant Health Oncology Specialists

Winston-Salem, North Carolina 27103, United States

Cleveland Clinic Taussig Cancer Center

Cleveland, Ohio 44106, United States

Cleveland Clinic

Cleveland, Ohio 44195, United States

James Cancer Hospital and Solove Research Institute

Columbus, Ohio 43210, United States

The Ohio State University - GU Clinic

Columbus, Ohio 43210, United States

The Ohio State University

Columbus, Ohio 43210, United States

Cancer Care Associates Medical Oncology

Allentown, Pennsylvania 18104, United States

St.Luke's Hospital-Allentown Campus

Allentown, Pennsylvania 18104, United States

Cancer Care Associate Medical Oncology

Bethlehem, Pennsylvania 18015, United States

St. Lukes University Health Network

Bethlehem, Pennsylvania 18015, United States

St.Luke's Cancer Center Anderson

Easton, Pennsylvania 18045, United States

St.Luke's Hospital-Anderson Campus

Easton, Pennsylvania 18045, United States

Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania 19104, United States

Investigational Drug Service, University of Pennsylvania

Philadelphia, Pennsylvania 19104, United States

St.Luke's Quakertown Hospital

Quakertown, Pennsylvania 18951, United States

Henry-Joyce Cancer Clinic

Nashville, Tennessee 37232, United States

Texas Oncology - Baylor Charles A. Sammons Cancer Center

Dallas, Texas 75246, United States

Texas Oncology - Gulf Coast

Houston, Texas 77024, United States

The University of Texas MD Anderson Cancer Center

Houston, Texas 77030, United States

Investigational Product Center (IPC)

Irving, Texas 75063, United States

Investigational Products Center (IPC)

Irving, Texas 75063, United States

Investigational Products Center (lPC)

Irving, Texas 75063, United States

US Oncology Investigational Products Center (IPC)

Irving, Texas 75063, United States

Joe Arrington Cancer Research and Treatment Center

Lubbock, Texas 79410, United States

Rainier Hematology-Oncology, PC

Puyallup, Washington 98373, United States

Fred Hutchinson Cancer Center

Seattle, Washington 98109, United States

University of Washington Medical Center

Seattle, Washington 98195, United States

Northwest Medical Specialties, PLLC

Tacoma, Washington 98405, United States

Macquarie University Hospital Pharmacy

Macquarie University, New South Wales 2109, Australia

Macquarie University

Macquarie University, New South Wales 2109, Australia

Nuclear Medicine Department

Randwick, New South Wales 2031, Australia

Pharmacy Department, Clinical Trials

Randwick, New South Wales 2031, Australia

Prince of Wales Hospital

Randwick, New South Wales 2031, Australia

Spectrum Medical Imaging

Randwick, New South Wales 2031, Australia

Division of Cancer Services

Woolloongabba, Queensland 4102, Australia

BHS Diagnostic Services

Ballarat, Victoria 3350, Australia

Lake Imaging

Ballarat, Victoria 3350, Australia

Box Hill Hospital

Box Hill, Victoria 3128, Australia

Eastern Health

Box Hill, Victoria 3128, Australia

Monash Health Translational Precinct, Monash Medical Centre

Clayton, Victoria 3168, Australia

Monash Medical Centre

Clayton, Victoria 3168, Australia

Monash Cancer Centre

East Bentleigh, Victoria 3165, Australia

Moorabbin Radiology

East Bentleigh, Victoria 3165, Australia

Slade Health

Mount Waverley, Victoria 3149, Australia

Ballarat Day Procedure Centre

Wendouree, Victoria 3355, Australia

Ballarat Oncology & Haematology Services

Wendouree, Victoria 3355, Australia

Nova Pharmacy

Wendouree, Victoria 3355, Australia

SKG Radiology

Murdoch, Western Australia 6050, Australia

Fiona Stanley Hospital

Murdoch, Western Australia 6150, Australia

SKG Radiology

Murdoch, Western Australia 6150, Australia

St John of God Murdoch Hospital

Murdoch, Western Australia 6150, Australia

EPIC Pharmacy Murdoch

Perth, Western Australia 6150, Australia

Krankenhaus der Barmherzigen Schwestern Wien

Vienna, 1060, Austria

Medizinische Universitaet Wien

Vienna, 1090, Austria

Cliniques Universitaires Saint-Luc

Brussels, 1200, Belgium

UZ Gent

Ghent, 9000, Belgium

AZ Groeninge

Kortrijk, 8500, Belgium

CHU de Liège

Liège, 4000, Belgium

Foothills Medical Centre

Calgary, Alberta T2N 2T9, Canada

Alberta Health Services - Cancer Care, Tom Baker Cancer Centre

Calgary, Alberta T2N 4N2, Canada

Cross Cancer Institute

Edmonton, Alberta T6G 1Z2, Canada

British Columbia Cancer Agency - Sindi Ahluwalia Hawkins Centre for the Southern Interior

Kelowna, British Columbia V1Y 5L3, Canada

British Columbia Cancer Agency

Vancouver, British Columbia V5Z 4E6, Canada

BC Cancer GU Clinic - Fairmont Medical Building

Vancouver, British Columbia V5Z IH7, Canada

London Regional Cancer Program, London Health Sciences Centre

London, Ontario N6A 4L6, Canada

London Regional Cancer Program, London Health Sciences Centre

London, Ontario N6A 5W9, Canada

R.S. McLaughlin Durham Regional Cancer Centre, Lakeridge Health

Oshawa, Ontario L1G 2B9, Canada

Sunnybrook Research Institute

Toronto, Ontario M4N 3M5, Canada

Jewish General Hospital

Montreal, Quebec H3T 1E2, Canada

CIUSSS de l'Estrie-Centre hospitalier universitaire de Sherbrooke

Sherbrooke, Quebec J1H 5N4, Canada

Herlev Hospital, Onkologisk Afdeling R

Herlev, 2730, Denmark

Odense Universitetshospital

Odense C, 5000, Denmark

Centre Eugene Marquis Service Pharmacie - Essais Cliniques

Rennes, Cedex 35042, France

Centre Francois Baclesse

Caen, 14076, France

Centre de Cancérologie de la Sarthe (CCS) - Clinique Victor Hugo

Le Mans, 72000, France

Clinique Victor Hugo Centre de Cancerologie de la Sarthe

Le Mans, 72000, France

Centre Léon Bérard

Lyon, 69008, France

Centre Léon Bérard

Lyon, 69373, France

Institut Paoli Calmettes

Marseille, 13009, France

Centre Eugene Marquis

Rennes, 35042, France

Institut de Cancérologie de l'Ouest - Centre René Gauducheau

Saint-Herblain, 44805, France

Institut de Cancerologie de Lorraine (ICL)

Vandœuvre-lès-Nancy, 54519, France

Institut de Cancerologie de Lorraine

Vandœuvre-lès-Nancy, 54519, France

Institut Gustave Roussy

Villejuif, 94805, France

Universitaetsklinikum Tuebingen

Tübingen, Baden-Wurttemberg 072076, Germany

Universitaetsklinikum Tuebingen

Tübingen, Baden-Wurttemberg 72076, Germany

Universitaetsklinikum Jena

Jena, Thuringia 07743, Germany

Universitaetsklinikum Jena Klinik und Poliklinik fuer Urologie

Jena, Thuringia 07747, Germany

Universitaetsklinikum Jena

Jena, Thuringia 07747, Germany

Dél.pesti Centrumkórház-OHII Szent Lálszló Kórház telephely

Budapest, 1097, Hungary

Országos Onkológiai Intézet

Budapest, 1122, Hungary

The Chaim Sheba Medical Center

Tel Litwinsky, Ramat - GAN 5265601, Israel

Assaf Harofe MC

Beer Yaakov, 70300, Israel

Shamir Medical Center

Beer Yaakov, 70300, Israel

Rambam Health Care Campus

Haifa, 31096, Israel

Rambam Healthcare Campus

Haifa, 31096, Israel

Meir Medical Center

Kfar Saba, 44281, Israel

Rabin Medical Center

Petah Tikva, 49100, Israel

The Chaim Sheba Medical Center

Ramat Gan, 5265601, Israel

Pharmacy - clinical unit, Tel Aviv Sourasky Medical Center

Tel Aviv, 6423906, Israel

Tel Aviv Sourasky Medical Center

Tel Aviv, 6423906, Israel

Centro di Riferimento Oncologico - IRCCS

Aviano, (PN) 33081, Italy

Farmacia Studi Clinici

Rozzano, Milan 20089, Italy

Istituto Clinico Humanitas

Rozzano, Milan 20089, Italy

Fondazione IRCCS Istituto Nazionale dei Tumori

Milan, 20133, Italy

SC Farmacia

Milan, 20133, Italy

Istituto Europeo di Oncologia

Milan, 20141, Italy

Servizio di Farmacia

Milan, 20141, Italy

Azienda Ospedaliera San Camillo Forlanini

Rome, 00152, Italy

Nagoya University Hospital

Nagoya, Aichi-ken 466-8560, Japan

Hirosaki University School of Medicine & Hospital

Hirosaki, Aomori 036-8563, Japan

Hokkaido University Hospital

Sapporo, Hokkaidô 060-8648, Japan

Iwate Medical University Hospital

Shiwa-gun, Iwate 028-3695, Japan

Yokohama City University Hospital

Yokohama, Kanagawa 236-0004, Japan

Kindai University Hospital

Sayama, Osaka 589-8511, Japan

Osaka University Hospital

Suita, Osaka 565-0871, Japan

Hamamatsu University School of Medicine, University Hospital

Hamamatsu, Shizuoka 431-3192, Japan

Keio University Hospital

Shinjuku-ku, Tokyo 160-8582, Japan

Tokyo Women's Medical University Hospital

Shinjuku-ku, Tokyo 162-8666, Japan

Akita University Hospital

Akita, 010-8543, Japan

Chiba Cancer Center

Chiba, 260-8717, Japan

Kyushu University Hospital

Fukuoka, 812-8582, Japan

Niigata University Medical & Dental Hospital

Niigata, 951-8520, Japan

Tokushima University Hospital

Tokushima, 770-8503, Japan

Yamagata University Hospital

Yamagata, 990-9585, Japan

Instituto Nacional de Cancerologia

Mexico City, Mexico City 14080, Mexico

Hospital Universitario Dr. Jose Eleuterio Gonzalez, Centro Universitario Contra el Cancer

Monterrey, Nuevo León 64460, Mexico

Oaxaca Site Management Organization S.C.

Oaxaca City, 68000, Mexico

Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital

Amsterdam, North Holland 1066 CX, Netherlands

Netherlands Cancer Institute / Apotheek MC Slotervaart

Amsterdam, North Holland 1066 EC, Netherlands

VU University Medical Center (VUmc)

Amsterdam, North Holland 1081 BT, Netherlands

VU University Medical Center (VUmc)

Amsterdam, North Holland 1081 HZ, Netherlands

Sint Franciscus Gasthuis, Pharmacy

Rotterdam, South Holland 3045 PM, Netherlands

Sint Franciscus Gasthuis

Rotterdam, South Holland 3045 PM, Netherlands

Maxima Medisch Centrum

Eindhoven, 5631 BM, Netherlands

St Apotheek der Haarlemse Ziekenhuizen

Haarlem, 2035 RC, Netherlands

Spaarne Gasthuis

Hoofddorp, 2134 TM, Netherlands

Maastricht University Medical Center

Maastricht, 6229 HX, Netherlands

Maxima Medisch Centrum

Veldhoven, 5504 DB, Netherlands

Maxima Medisch Centrum

Veldhoven, 5504 DL, Netherlands

Auckland City Hospital

Grafton, Auckland 1023, New Zealand

Tauranga Hospital, Bay of Plenty Clinical Trials Unit

Tauranga, Bay of Plenty 3143, New Zealand

Palmerston North Hospital

Palmerston North, Manawatu-Wanganui 4414, New Zealand

Tauranga Hospital

Tauranga Bay of Plenty, Tauranga 3112, New Zealand

Wairarapa District Health Board

Masterton, Wairarapa 5840, New Zealand

Auckland City Hospital Pharmacy

Auckland, 1023, New Zealand

Baxter Healthcare New Zealand

Auckland, 1060, New Zealand

Christchurch Hospital

Christchurch, 8140, New Zealand

Waikato Hospital Pharmacy Services

Hamilton, 3240, New Zealand

Waikato Hospital

Hamilton, 3240, New Zealand

Broadway Radiology

Palmerston North, 4410, New Zealand

"Prof. Dr. Ion Chiricuta" Oncology Institute

Cluj-Napoca, 400015, Romania

S.C. Medisprof S.R.L.

Cluj-Napoca, 400641, Romania

"Sfantul Nectarie" Oncology Center

Craiova, 200347, Romania

Oncomed SRL

Timișoara, 300239, Romania

RBHI "Kursk Regional Clinical Oncology Dispensary" of HCKR (legal address)

Kursk, Kursk Oblast 305035, Russia

RBHI "Kursk Regional Clinical Oncology Dispensary" of HCKR

Kursk, Kursk Oblast 305524, Russia

Russian Research Center for Radiology and Surgical Technologies

Saint Petersburg, Pesochny 197758, Russia

FSBI "Research Institute of Oncology n.a. N.N. Petrov" MoH RF

Saint Petersburg, Poselok Pesochniy 197758, Russia

Private Medical Institution "Euromedservice"

Pushkin, Sankt-Peterburg 196603, Russia

Scientific Research Institute of Urology named after N.A.Lopatkin of the Hersten Federal

Moscow, 105425, Russia

Moscow Scientific Research Oncology Institute n.a. P.A. Hertzen

Moscow, 125284, Russia

FBIH "Privolzhskiy Regional Medical Center" of FMBA

Nizhny Novgorod, 603001, Russia

SBIH of Nizhegorodskaya region "Clinical-Diagnostics center"

Nizhny Novgorod, 603006, Russia

FBIH "Privolzhskiy Regional Medical Center" of FMBA

Nizhny Novgorod, 603032, Russia

FBIH "Privolzhskiy Regional Medical Center" of FMBA

Nizhny Novgorod, 603109, Russia

SBIH of Nizhegorodskaya region "Nizhniy Novgorod Regional Clinical Oncology Dispensary"

Nizhny Novgorod, 603126, Russia

Clinical Hospital #122 n.a. L. G. Sokolov

Saint Petersburg, 194291, Russia

NS HI "Road Clinical Hospital of JSC "Russian Railways""

Saint Petersburg, 195271, Russia

LLC "Diagnostic center "Energo"

Saint Petersburg, 196247, Russia

LLC "Clinical Diagnostic Center "Medex-pert"

Yaroslavl, 150014, Russia

SHI YR Regional Clinical Oncology Hospital

Yaroslavl, 150040, Russia

Clinical Trial Pharmacy, National Cancer Center

Goyang-si, Gyeonggi-do 10408, South Korea

National Cancer Center

Goyang-si, Gyeonggi-do 10408, South Korea

Seoul National University Bundang Hospital, Clinical Pharmacy

Seongnam-si, Gyeonggido 13620, South Korea

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggido 13620, South Korea

Kyungpook National University Medical Center, Clinical Pharmacy

Daegu, 41404, South Korea

Kyungpook National University Medical Center

Daegu, 41404, South Korea

Chungnam National University Hospital, Clinical Pharmacy

Daejeon, 35015, South Korea

Chungnam National University Hospital

Daejeon, 35015, South Korea

Seoul National University Hospital, Clinical Pharmacy

Seoul, 03080, South Korea

Seoul National University Hospital

Seoul, 03080, South Korea

Severance Hospital, Yonsei University Health System

Seoul, 03722, South Korea

Asan Medical Center

Seoul, 05505, South Korea

Clinical Trial Pharmacy

Seoul, 05505, South Korea

Samsung Medical Center Clinical Trial Pharmacy

Seoul, 06351, South Korea

Samsung Medical Center

Seoul, 06351, South Korea

Clinica Universidad de Navarra

Pamplona, Navarre 31008, Spain

Hospital Universitario Ramon y Cajal

Madrid, 28034, Spain

Hospital Universitario Virgen del Rocio

Seville, 41013, Spain

Sahlgrenska University Hospital, Dept of Oncology

Gothenburg, 413 45, Sweden

Cambridge University Hospital NHS Foundation Trust, Addenbrooke's Hospital

Cambridge, Cambridgeshire CB2 0QQ, United Kingdom

Mount Vernon Cancer Centre, East & North Herts NHS Trust

London, Middlesex HA6 2RN, United Kingdom

Mount Vernon Cancer Centre, Pharmacy

London, Middlesex HA6 2RN, United Kingdom

The Royal Marsden NHS Foundation Trust

Sutton, Surrey, London SM2 5PT, United Kingdom

The Royal Marsden NHS Foundation Trust

Sutton, Surrey SM2 5PT, United Kingdom

Addenbrooke's Hospital, Central Pharmacy, Level 1

Cambridge, CB2 0QQ, United Kingdom

Beatson WOSCC

Glasgow, G12 0YN, United Kingdom

Beatson West of Scotland Cancer Centre, Gartnavel General Hospital,

Glasgow, G120YN, United Kingdom

St Bartholomew's Hospital, Barts Health NHS Trust

London, EC1A 7BE, United Kingdom

The Royal Marsden NHS Foundation Trust

London, SW3 6JJ, United Kingdom

Clinical Trials Pharmacy, The Christie

Manchester, M20 4BX, United Kingdom

Department of Medical Oncology, The Christie NHS Foundation Trust

Manchester, M20 4BX, United Kingdom

Academic Unit of Oncology, Nottingham University Hospitals NHS Trust-City Campus

Nottingham, NG5 1PB, United Kingdom

Nottingham University Hospitals, Nottingham City Hospital, Nottingham Trials Pharmacy

Nottingham, NG5 1PB, United Kingdom