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| Name | Class |
|---|---|
| Benha University | OTHER |
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We aimed to investigate the efficiency of chemical oocyte activation using readymade Ca2+ ionophore on cases with previously cancelled cases due to fertilization arrest at pronuclear stage i.e: cleavage failure to find out if there is any improvement in embryonic developmental stages.
Many studies reported that Ca2+ ionophore has a positive effect on embryo development in cases with complete or partial fertilization failure. However, only one preliminary report suggested a beneficial effect of Ca2+ ionophore activation in four cases with fertilization arrest.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Without Ca2+ ionophore | No Intervention | Patients with previous incomplete ICSI cycle due to fertilization arrest were counseled to underwent a subsequent conventional ICSI cycle. | |
| With Ca2+ ionophore | Experimental | Patients with previous incomplete ICSI cycle due to fertilization arrest were counseled to underwent a subsequent ICSI cycle combined with artificial oocyte activation using Ca2+ ionophore. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ca2+ ionophore | Other | Ca2+ ionophore is a chemical agent used to perform oocyte activation after ICSI. It showed effective treatment to get better fertilization, pregnancy, and healthy livebirth in cases with total or partial fertilization failure. |
| Measure | Description | Time Frame |
|---|---|---|
| Blastocyst formation rate | Defined as the total number of blastocyst / total number of cleaved Embryos | 5 to 7days post oocyte retrival |
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yasmin Magdi, M.Sc | Contact | +201282313979 | Yas.magdi@hotmail.com | |
| Ahmed El-Damen, M.Sc | Contact | +201002414342 | Ahmed_eldamen@Yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Yasmin Magdi, M.Sc | Dar Almaraa fertility and gynacology center | Principal Investigator |
| Mona M. Awady, MD | Department of Community Medicine, Faculty of Medicine, Benha University, Benha, Egypt | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ahmed el-Damen | Recruiting | Cairo | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 22921909 | Background | Ebner T, Koster M, Shebl O, Moser M, Van der Ven H, Tews G, Montag M. Application of a ready-to-use calcium ionophore increases rates of fertilization and pregnancy in severe male factor infertility. Fertil Steril. 2012 Dec;98(6):1432-7. doi: 10.1016/j.fertnstert.2012.07.1134. Epub 2012 Aug 24. | |
| 25596904 | Background |
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| Ebner T, Montag M; Oocyte Activation Study Group; Montag M, Van der Ven K, Van der Ven H, Ebner T, Shebl O, Oppelt P, Hirchenhain J, Krussel J, Maxrath B, Gnoth C, Friol K, Tigges J, Wunsch E, Luckhaus J, Beerkotte A, Weiss D, Grunwald K, Struller D, Etien C. Live birth after artificial oocyte activation using a ready-to-use ionophore: a prospective multicentre study. Reprod Biomed Online. 2015 Apr;30(4):359-65. doi: 10.1016/j.rbmo.2014.11.012. Epub 2014 Dec 9. |
| 26507280 | Result | Darwish E, Magdi Y. A preliminary report of successful cleavage after calcium ionophore activation at ICSI in cases with previous arrest at the pronuclear stage. Reprod Biomed Online. 2015 Dec;31(6):799-804. doi: 10.1016/j.rbmo.2015.08.012. Epub 2015 Aug 28. |