The purpose of this study is to determine whether Lovastatin, Minocycline and the combination Lovastatin/Minocycline are effective in treating behavioral symptoms in Fragile X individuals.

Inclusion Criteria:

• Molecular diagnosis of fragile X syndrome
• The participant must be accompanied his parent, legal tutor or legal representative.
• Identify a caregiver who spends at least six hours per day with the participant (may be the parent, legal tutor, legal representative or an other person).
• IQ < 70
• ABC-C score > 20
• CGI-Severity score ≥ 4

Exclusion Criteria:

• Pregnant or breastfeeding participants

• Previous intolerance/allergy to statins, minocycline or tetracyclines

• Participants who have taken lovastatin or minocycline in the last 12 weeks

• Personal history of myopathy, myalgia or high creatine kinase (CK) levels

• Renal disease / liver disease / disturbed hepatorenal tests

• Participants taking more than three psychoactive medications (except anticonvulsants)

• Untreated or uncontrolled hypothyroidism

• Any other active medical condition

• Modification of psychoactive treatment in the last 6 weeks prior to randomization

• Participants under the age of 13 years who have incomplete formation of the crown of their teeth (except possibly their 3rd molars) as shown by panorex

• Concomitant use of prohibited drugs

  • Prohibited drugs include other hypolipemic including gemfibrozil (or other fibrates) and niacin (nicotinic acid), angiotensin converting enzyme (ACE), cyclosporine, danazol, amiodarone, verapamil and inhibitors P450 (CYP3A4) (itraconazole, ketoconazole, erythromycin, clarithromycin, telithromycin, inhibitors of HIV protease and nefazodone).