Effect of Toothpaste Fortified With Cyanocobalamin on Vitamin B12 Status

Effect of Toothpaste Fortified With Cyanocobalamin on Vitamin B12 Status: A 3 Month Placebo Controlled Randomized Study

A 3 months randomized, placebo-controlled study on the effect of toothpaste fortified with vitamin B12 on vitamin B12 status markers and related metabolic markers. The primary outcome variable is the difference in the change of methylmalonic acid after 3 months between the two study arms.

Inclusion Criteria:

• Adults: men and women
• Stable diet for at least 24 months (omnivorous or a vegan diet).

Exclusion Criteria:

• Pregnancy and lactation
• Malabsorption disorders (Crohn disease, chronic gastritis, pernicious anemia, gastric or intestinal resection)
• Renal diseases
• Liver diseases
• Patients with cancer (or cancer history)
• Pre-study treatment with vitamin B12 or folate