The SLIM Study: Sling and Botox® Injection for Mixed Urinary Incontinence

The SLIM Study: Sling and Botox® Injection for Mixed Urinary Incontinence

This double-blind randomized controlled trial seeks to find a better treatment for women with mixed urinary incontinence (both stress and urgency incontinence). The primary aim is to determine whether midurethral sling surgery combined with injections of onabotulinumtoxinA (Botox®) into the detrusor muscle of the bladder improves symptoms of mixed urinary incontinence better than sling surgery alone.

Inclusion Criteria:

• Undergoing mid-urethral sling surgery
• Have symptoms of both stress and urgency urinary incontinence
• Able to consent, fill out study documents, and complete all study procedures and follow-up visits
• At least 18 years of age
• English speaking
• Be able and willing to learn clean intermittent self catheterization technique

Exclusion Criteria:

• History of recurrent UTI (defined as three culture proven UTIs within last 12 months)
• Systemic neuromuscular disease known to affect the lower urinary tract
• Undergoing concomitant prolapse surgery
• Previous incontinence surgery
• Treatment with anticholinergic medication in the last 2 months
• Previous bladder injection with onabotulinumtoxinA
• Prisoner Status
• Pregnancy