Accelerated Wound Healing in Diabetic Ulcers by Sitagliptin

Accelerated Wound Healing in Diabetic Ulcers by Sitagliptin

The purpose of the study is to test the effect of Sitagliptin on the healing of stable, nonhealing diabetic foot ulcers. This is a randomized placebo-controlled Trial.

Inclusion Criteria:

• type 2 diabetes mellitus
• at least 1 diabetic foot ulcer with a size between 1 and 20 sqcm
• stable size of the foot ulcer for at least 2 weeks
• HbA1c <= 8% under Treatment with Insulin, metformin, sulfonylureas, SGLT2 Inhibitors, glinides or glitazones

Exclusion Criteria:

• local purulent signs of Inflammation at ulcer site
• planned interventional or surgical therapy of a macro vessel disease of the lower limb
• glomerular filtration rate <30ml/min
• liver cirrhosis CHILD B or C
• pregnancy, lactation
• allergy against Sitagliptin
• ongoing treatment with dipeptidyl peptidase 4 (DPP4) Inhibitors