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| Name | Class |
|---|---|
| National Institute on Deafness and Other Communication Disorders (NIDCD) | NIH |
| National Institute on Aging (NIA) | NIH |
| Johns Hopkins University | OTHER |
The goal of this study is to remediate word-finding problems in patients who have Primary Progressive Aphasia (PPA) or Alzheimer's Disease and to delay the further progression of word-finding impairment. The current approach is novel in that it contains a prophylaxis component in which the investigators attempt to strengthen neural connections that remain functional, making them more resistant to degradation as the disease progresses. While the study is specific in its targeting of word-finding problems, a successful outcome would bode well for other studies aimed at prevention or reversal of declining cognitive functions in dementia. One set of participants with PPA will receive practice with picture naming in two conditions: viewing the picture and repeating the name; and viewing the picture with its written name, plus reading and writing the name. Another set of participants with PPA or Alzheimer's Disease will be trained in two different conditions: learning about the word's semantic features (meaning); and learning about the word's lexical features (letters and sounds). Naming of pictures trained in each of these conditions will be compared, at three time intervals post-training, with naming of pictures tested before the study but never trained. It is predicted that the pairing of the picture with its written name, combined with the motor task of writing the name, will result in a greater ability to name the picture at a later date than simple practice viewing the picture and repeating the name. Furthermore, it is predicted that participants who have difficulty understanding concepts will be more likely to respond to semantic treatment, while participants who have difficulty connecting words with concepts will be more likely to respond to lexical treatment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Phonological, Orthographic, Untrained | Experimental |
| |
| Semantic, Lexical, Untrained | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Phonological | Behavioral | This treatment involves picture viewing and word repetition. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in picture naming accuracy for words within each treatment condition during treatment | The change in picture naming accuracy for trained words will be compared with the change in picture naming accuracy for words that were tested at baseline but never trained during the treatment phase. | baseline, 7 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in picture naming accuracy for words within each treatment condition between baseline and first follow-up assessment | The change in picture naming accuracy for trained words will be compared with the change in picture naming accuracy for words that were tested at baseline but never trained during the treatment phase. | baseline, 14 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Aaron Meyer, PhD | Georgetown University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Georgetown University Medical Center | Washington D.C. | District of Columbia | 20057 | United States | ||
| Johns Hopkins University |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40857539 | Derived | Suh S, Friedman RB, Meyer AM, Snider SF, Sebastian R, Tippett DC. Picture Description and Functional Communication Rating Correlates in Variants of Primary Progressive Aphasia. Aphasiology. 2025 May 28:10.1080/02687038.2025.2510327. doi: 10.1080/02687038.2025.2510327. Online ahead of print. |
| Label | URL |
|---|---|
| Center for Aphasia Research and Rehabilitation website | View source |
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| ID | Term |
|---|---|
| D018888 | Aphasia, Primary Progressive |
| D000849 | Anomia |
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| Orthographic | Behavioral | This treatment involves picture viewing, reading, and writing. |
|
| Semantic | Behavioral | This treatment involves learning about the semantic features (meaning) of each trained word. |
|
| Lexical | Behavioral | This treatment involves learning about the lexical features (letters and sounds) of each trained word. |
|
| Untrained | Behavioral | These words are not trained during the treatment phase. |
|
| Change in picture naming accuracy for words within each treatment condition between baseline and second follow-up assessment | The change in picture naming accuracy for trained words will be compared with the change in picture naming accuracy for words that were tested at baseline but never trained during the treatment phase. | baseline, 21 months |
| Baltimore |
| Maryland |
| 21287 |
| United States |
| D001037 |
| Aphasia |
| D013064 | Speech Disorders |
| D007806 | Language Disorders |
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D024801 | Tauopathies |
| D019636 | Neurodegenerative Diseases |