A single center, self-controlled pilot study on safety and efficacy of renal denervation in treatment of hypertension.

Inclusion Criteria:

• Ages of 18 to 75, male or female;

• Main renal artery, with or without accessary renal arteries, with length

  • 20mm;

• Patients who have not taken any anti-hypertensive drugs or have been off drugs for at least 2 weeks, with mean SBP ≥150mmHg and

  • 180mmHg based on at least 3 office blood pressure measurements, or ASBP≥135mmHg and ≤170mmHg based on 24 hr blood pressure monitoring;

• Agrees to take part in the trial and signs the written, informed consent.

Exclusion Criteria:

• Renal artery abnormalities that are inappropriate for the procedure;
• Pregnant or plan to become pregnant;
• History of orthostatic hypotension;
• Type I diabetes;
• Estimated GFR<40mL/min/1.73m2;
• Only one kidney or prior kidney transplantation;
• Bleeding tendency or other coagulation related diseases;
• Acute or severe systemic infection;
• Prior renal artery interventional procedures or prior RDN treatment;
• History of stroke or TIA;
• Malignant tumor or end-stage illnesses;
• Secondary hypertension;
• Acute coronary events within 2 weeks;
• Other conditions that deem unsuitable for the procedure, in the opinions of investigators.