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Non-adherence to medications can lead to sub-optimal treatment in rheumatoid arthritis (RA) patients. In order to improve disease modifying anti-rheumatic drugs (DMARDs) adherence, the investigators are conducting a randomized controlled trial to test out an intervention to improve medications adherence among low adherers. This intervention involves the use of a musculoskeletal ultrasound program which allows RA patients to visualize their joint inflammation and damage real time while treatment adherence is simultaneously reinforced. In doing so, the investigators hope to improve patients' understanding of their joint disease and motivate the participants to adhere to their medications.
This is a single center randomized controlled clinical trial conducted in the Singapore General Hospital. Eligible RA subjects meeting the inclusion and exclusion criteria will be screened using a medication adherence measure questionnaire. Thereafter 132 patients who are low adherers on the questionnaire will then be recruited and randomized (in a 1:1 ratio) to either (a) intervention arm (with musculoskeletal US program) or (b) control arm (without musculoskeletal US program), and followed up over a period of about 6 month.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Musculoskeletal ultrasound program | Other | Participants will receive the musculoskeletal ultrasound program |
|
| Control | No Intervention | Participants will not be receiving the musculoskeletal ultrasound program. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Musculoskeletal ultrasound program | Behavioral | Using a musculoskeletal ultrasound program to help improve medication adherence |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in proportion of patients with a low adherence score using medication adherence measure (questionnaire) | baseline and 1 month |
| Measure | Description | Time Frame |
|---|---|---|
| Change in proportion of patients with a low adherence score using medication adherence measure (questionnaire) | baseline, 3 months and 6 months | |
| Change in proportion of patients with a low adherence score using medication adherence measure (pharmacy dispense data) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in clinical follow-up defaults (e.g. how often patients do not show up for their clinic appointments) | baseline, 3 months and 6 months | |
| Change in clinical joint assessment outcomes(e.g. disease activity score 28) | baseline, 3 months and 6 months |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Tan | Singapore General Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Singapore | Singapore |
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| ID | Term |
|---|---|
| D001172 | Arthritis, Rheumatoid |
| ID | Term |
|---|---|
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
| D012216 | Rheumatic Diseases |
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| baseline, 1 month, 3months and 6 months |
| D003240 |
| Connective Tissue Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |