Evaluation of the Effect of Appropriate Sedation for Patients After Abdominal Surgeries : A Prospective Randomised Controlled Study

To evaluate the efficacy and safety of appropriate postoperative sedation with dexmedetomidine for patients after abdominal surgeries.Prospective randomised controlled study was conducted among patients after abdominal surgeries began in October 2015.The investigators enroll patients who received abdominal surgeries. One group receive sedative along with analgesic and the other group analgesic only for the other group on the first 24 hours after surgeries and will follow up for 3 days.

Inclusion Criteria

• 16-85 years old
• underwent abdominal surgeries including enterectomy, gastrectomy, hepatectomy and pancreatectomy in the hospital and operation duration lasted at least 2 hours.

Exclusion Criteria

• take part in other clinical trials
• quinolone antibiotics intake 4 weeks prior to or within the study
• NSAIDS intake within one month
• history of peptic ulcer
• respiratory insufficiency
• renal insufficiency
• acute hepatitis or severe liver disease (Child-Pugh class C)
• pregnancy or lactation
• abnormal ECG with clinical significance
• uncontrolled hypotension
• bleeding tendency or hematological diseases
• untreated mechanical intestinal obstruction
• unable to express or any kind of mental disease.