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To evaluate the efficacy and safety of appropriate postoperative sedation with dexmedetomidine for patients after abdominal surgeries.Prospective randomised controlled study was conducted among patients after abdominal surgeries began in October 2015.The investigators enroll patients who received abdominal surgeries. One group receive sedative along with analgesic and the other group analgesic only for the other group on the first 24 hours after surgeries and will follow up for 3 days.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dexmedetomidine,tramadol and flurbiprofen | Experimental | Both routine analgesic and sedation(dexmedetomidine,tramadol and flurbiprofen) are applied for this group of patients. |
|
| Tramadol and flurbiprofen | Active Comparator | Only routine analgesic(Tramadol and flurbiprofen) is applied for this group of patients. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine, tramadol and flurbiprofen | Drug |
| ||
| tramadol and flurbiprofen |
| Measure | Description | Time Frame |
|---|---|---|
| postoperative pain | assessed by Prince Henry Pain Scale by investigators at 8:00 am after surgeries until discharge from ICU | 1-3d after abdominal surgeries |
| recovery of gastrointestinal function | assessed by time to first defecation | from admission to 30 days after abdominal surgeries |
| white blood cell count(10^9 /L) | evaluation of postoperative inflammatory response, blood sample collected at 6:00am for 1-3d after surgeries | 1-3d after abdominal surgeries |
| C-reactive protein(mg/L) | evaluation of postoperative inflammatory response, blood sample collected at 6:00am for 1-3d after surgeries | 1-3d after abdominal surgeries |
| Measure | Description | Time Frame |
|---|---|---|
| percentage of time within target sedation range | assessed by Richmond Agitation-Sedation Scale by investigators at 8:00 am after surgeries until discharge from ICU, target range is -2 to +1 | 1-3d after abdominal surgeries |
| risk of hypotension requiring interventions |
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Inclusion Criteria
Exclusion Criteria
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institute of General Surgery of Jinling Hospital | Nanjing | Jiangsu | 210002 | China |
basic characteristics of participant,interventions, primary and secondary outcomes, main results
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| Drug |
|
systolic blood pressure <80 mmHg or/and diastolic blood pressure <50 mmHg is considered hypotension |
| 1-3d after abdominal surgeries |
| risk of bradycardia requiring interventions | heart rate <40/min is considered bradycardia | 1-3d after abdominal surgeries |
| use of opioids and use of benzodiazepins | 1-3d after abdominal surgeries |
| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D014147 | Tramadol |
| D005480 | Flurbiprofen |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D003511 | Cyclohexanols |
| D000441 | Hexanols |
| D005233 | Fatty Alcohols |
| D000438 | Alcohols |
| D009930 | Organic Chemicals |
| D004123 | Dimethylamines |
| D008744 | Methylamines |
| D000588 | Amines |
| D008055 | Lipids |
| D011422 | Propionates |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D001713 | Biphenyl Compounds |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
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