A Single-center Pilot Study Evaluating the Immediate Effects of Low-dose Acetazolamide on Respiratory Control in Subjects With Treatment Emergent Sleep Disordered Breathing

A Single-center Pilot Study Evaluating the Immediate Effects of Low-dose Acetazolamide on Respiratory Control in Subjects With Treatment Emergent Sleep Disordered Breathing

This is a single center pilot study evaluating the immediate effects of low-dose acetazolamide on respiratory control in subjects with treatment emergent sleep disordered breathing. The purpose of this study is to assess the immediate effect one-time low-dose acetazolamide on sleep breathing in (Treatment Emergent Sleep Disordered Breathing) TE-CSA subjects compared to subjects' baseline evaluation without acetazolamide. Investigators will also try to determine the immediate effect of one-time low-dose acetazolamide on subjects' resting ventilation and ventilatory response slope compared to subjects' baseline evaluation without acetazolamide.

Inclusion Criteria:

• Age ≥18 to 80 years
• TE-CSA
• Subjects are capable of giving informed consent

Exclusion Criteria:

• Hypersensitivity to acetazolamide or other sulfonamides
• Intake of carbonic anhydrase inhibitors within the last 72 hours
• Intake of medication that influences breathing, sleep, arousal or muscle physiology
• Cheyne-Stokes respiration
• Heart failure
• Renal failure
• Liver failure
• Chronic hypercapnea
• Hyponatremia
• Hypokalemia
• Pregnancy
• Breastfeeding mothers
• Active drug/alcohol dependence or abuse history