Pain is a common side effect of propofol injection. The purpose of this study was to compare the efficacy of pregabalin and lidocaine in reducing propofol injection pain.

In a randomized, double blind, prospective trial, 120 patients were allocated to one of three groups (each n=40) receiving intravenous lidocaine 40mg (group L), oral pregabalin 75 mg (group LP), and oral pregabalin 150 mg (group HP) as pretreatment, followed by injection of 25% of 2 mg/kg propofol. Pain was assessed by a four point scale (0=no, 1=mild, 2=moderate, 3=severe pain).

Inclusion Criteria:

• Patient underwent elective dental surgery.

Exclusion Criteria:

• Patient with a history of adverse response to lidocaine or pregabalin,
• Patient with cardiovascular or respiratory disease,
• Patient who takes any sedatives, analgesics, or anticonvulsants within 24 hours before surgery.