The Effect of a Low FODMAP Oral Nutrition Supplement On Breath Hydrogen Response In Healthy Human Subjects

The Effect of a Low FODMAP Oral Nutrition Supplement On Breath Hydrogen Response In Health Human Subjects

The goal of this study is to determine subjective gastrointestinal tolerance response and differences in breath hydrogen response following the consumption of different types of low FODMAP oral nutrition supplements. This randomized, crossover study requires participants to arrive to the lab 12 hours fasted, consume an oral liquid supplement and complete gastrointestinal tolerance questionnaires as well as produce samples for breath hydrogen analysis at various time points over a 4 hour time period.

This randomized, crossover study requires participants to arrive to the lab 12 hours fasted, consume an oral liquid supplement and complete gastrointestinal tolerance questionnaires as well as produce samples for breath hydrogen and methane analysis at various time points over a 4 hour time period. Subjects will also be asked to rate gastrointestinal symptoms via a questionnaire at various time points throughout the study.

Inclusion Criteria:

• Between the ages of 18-65 years with a body mass index between 18-29 kg/m2.
• Demonstrates spoken and written English literacy and able to provide written, informed consent after review of study protocol and procedures.

Exclusion Criteria:

• Use of enemas, proton pump inhibitors, or antibiotics within the past 3 months
• Smoker
• Not a regular breakfast eater
• Self-reported history of a past or current gastrointestinal disease
• High fiber eater (> or = to 3 servings of high fiber foods per day)
• Concurrent or recent (within 30 days) participation in an intervention trial
• Recent weight fluctuations
• Allergies to any of the test products