Personalised Postoperative Radiochemotherapy in Patients With Head and Neck Cancer

Personalised Postoperative Radiochemotherapy in Patients With Head and Neck Cancer and Development of a Multi-parametric Decision Support System for Personalised Medicine in Radiation Oncology

The current trial is evaluating the integration of a pretherapeutical FDG-PET/MRI in the adjuvant radiochemotherapy in patients with head and neck cancer. As a secondary hypothesis the intention is to develop of a multi-parametric decision support system for personalised medicine by integrating functional imaging, γH2AX-analysis and genetic information.

Inclusion Criteria:

• locally-advanced HNSCC (Oro- and Hypopharynx) stage III and IV without distant metastases
• no contraindications for PET/MRI
• no contraindications for radiochemotherapy
• informed consent
• ECOG PS 0/2

Exclusion Criteria:

• Secondary malignancies that might influence outcome within 2 years after radiochemotherapy of the HNSCC
• previous PET/CT
• induction therapy
• pregnancy or breastfeeding