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The current trial is evaluating the integration of a pretherapeutical FDG-PET/MRI in the adjuvant radiochemotherapy in patients with head and neck cancer. As a secondary hypothesis the intention is to develop of a multi-parametric decision support system for personalised medicine by integrating functional imaging, γH2AX-analysis and genetic information.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Integration of PET/MRI in radiotherapy | Experimental | Integration of pretherapeutical PET/MRI in adjuvant radiotherapy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Integration of PET/MRI in radiotherapy | Radiation | Integration of pretherapeutical PET/MRI in adjuvant radiotherapy |
|
| Measure | Description | Time Frame |
|---|---|---|
| locoregional progression free survival | 15% improvement in loco-regional PFS at 2 years through integrtion of pre-operative PET/MR imaging into RT treatment planning | 2 years after primary diagnosis |
| Measure | Description | Time Frame |
|---|---|---|
| Disease free survival | 2 years after primary diagnosis | |
| Overall survival | 2 years after primary diagnosis | |
| Development of a multi-parametric decision support system |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Daniel Zips, MD, Prof | University Hospital Tuebingen, Department of Radiation Oncology, Tuebingen, Germany | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Tübingen, Department of Radiation Oncology | Tübingen | Baden-Wurttemberg | 72076 | Germany |
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| ID | Term |
|---|---|
| D006258 | Head and Neck Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D011878 | Radiotherapy |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
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| after termination of recruitment and follow up up to 5 years |