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| Name | Class |
|---|---|
| Sun Yat-sen University | OTHER |
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The purpose of the present study is to evaluate the safety and exploratory efficacy of the umbilical cord mesenchymal stem cells for patients with ischemic heart diseases.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| UCMSCs | Experimental | Intracoronary infusion of umbilical cord mesenchymal stem cells (UCMSCs) |
|
| controls | No Intervention | Standard medical treatment without umbilical cord mesenchymal stem cells (UCMSCs) infusion |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| umbilical cord mesenchymal stem cells | Biological |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in global left ventricular ejection fraction (LVEF)measured by echocardiography. | 1 week, 6 month, 12 month,18 month | |
| Change in infarct size and myocardial viability within the infarcted region measured by emission computed tomography (ECT). | 1 week, 18 month |
| Measure | Description | Time Frame |
|---|---|---|
| Pump failure Killip classification | baseline, 1 week, 1 month, 6 month, 12 month,18 month | |
| New York Heart Association(NYHA) classification | 1 week, 1 month, 6 month, 12 month,18 month | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xuetao Pei, M.D., Ph.D | Contact | 8610-68164807 | AMMS0906@163.com | |
| Junnian Zhou, Ph.D | Contact | 8620-89199011 | zhoujunnian@scrm.org.cn |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23651816 | Background | Gao LR, Pei XT, Ding QA, Chen Y, Zhang NK, Chen HY, Wang ZG, Wang YF, Zhu ZM, Li TC, Liu HL, Tong ZC, Yang Y, Nan X, Guo F, Shen JL, Shen YH, Zhang JJ, Fei YX, Xu HT, Wang LH, Tian HT, Liu DQ, Yang Y. A critical challenge: dosage-related efficacy and acute complication intracoronary injection of autologous bone marrow mesenchymal stem cells in acute myocardial infarction. Int J Cardiol. 2013 Oct 9;168(4):3191-9. doi: 10.1016/j.ijcard.2013.04.112. Epub 2013 May 4. |
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| Occurrence of major adverse event |
| 3 day, 1 week, 1 month, 6 month, 12 month,18 month |
| ID | Term |
|---|---|
| D009203 | Myocardial Infarction |
| ID | Term |
|---|---|
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D014652 | Vascular Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
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