Penile Intracavernosal Stem Cells Therapy for Erectile Dysfunction

Phase 1 Study of the Use of Autologous Penile Stem Cells in Men With Erectile Dysfunction

Autologous Fat Derived Stem Cell treatment of ED.

To assess safety and primary efficacy of stem cell infusion in refractory ED.

To investigate the success rate and durability of success of using this new therapy in management of moderate and sever cases of erectile dysfunction.

Inclusion Criteria:

• Male 40 years old and older suffering from moderate to sever erectile dysfunction -

Exclusion Criteria:

• Inability to give informed consent or attend follow up
• Severe diabetic neuropathy (to be defined ? Charcot joints, diabetic ulcers?) or other neuropathic disease
• Viral disease from infectivity viewpoint
• Major penile fibrosis or severe Peyronie's disease
• Severe primary large vessel ED (defined as PSV less than 15cm/s after ICI)
• Severe primary venous leakage ED (defined as EDV more than 10cm/s after ICI)
• Prior systemic chemotherapy, or radiotherapy to donor or recipient area
• Not in potentially active sexual relationship
• Age less than 40 or over 70