Prevention of Akute Kidney Injury, Hearttransplant, ANP

Prevention of Akute Kidney Injury With Human Atrial Natriuretic Peptide in Patients Undergoing Heart Transplant.

Prospective, blinded, placebo-controlled trial. Patients: Adult patients (>18 years of age) undergoing de novo Htx, with a preoperative GFR > 30ml/min, not receiving an ABO-incompatible organ with an ischemia time of > 6 hours. A donor age > 70 years is an exclusion criteria.

Intervention: Infusion of h-ANP fore five days, starting at the induction of anesthesia.

Outcome: Kidney function, evaluated with serum creatinine day 1-7 and kidney clearance, 4-5 Days after Htx plus after 3 and 12 months.

Inclusion Criteria:

• De novo Htx.
• Preoperative GFR > 30ml/min/1,73m2.
• >18 years old.
• Written consent.

Exclusion Criteria:

• Multi organ transplantation or previous heart transplant.
• ECMO
• Donor age > 70 years.
• Dialysis.
• ABO-incompatible organ.
• Donor heart ischemia time > 6 tim.
• Known kidney disease.
• Other planed study within 2 mounth.