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The purpose of this study is to learn more about the potential effects of visible light on the skin. More specifically, this study will examine whether an incandescent lamp (light bulb) or LED light bulb can cause skin to become darker. Investigators will determine the minimum threshold dose required to achieve immediate pigmentation darkening (IPD), persistent pigmentation darkening (PPD), and delayed tanning (DT) for Fitzpatrick skin types IV - VI utilizing two visible light sources.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy volunteers | Experimental | Healthy volunteers without cutaneous disorders associated with pigmentary changes |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Part A: Baseline-Week 2 | Other | The study doctor will shine 2 different light bulbs (one a regular or incandescent bulb and the other an LED light bulb) on 12 different areas of patients skin approximately 6 square centimeters in size (less than 1 square inch or the size of your thumb nail). Each light bulb will be exposed to your skin for approximately 20 - 35 minutes. After exposure, the study doctor will perform skin assessments at 3 time points:
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| Measure | Description | Time Frame |
|---|---|---|
| Diffuse Reflectance Spectroscopy (DRS) to examine the optical properties of melanin and deoxyhemoglobin | 12 weeks | |
| Quantification of the scattering and absorption properties of the skin in which the beam of light will penetrate using DRS | 12 weeks | |
| Measurement of pigmentation changes induced by the two light sources using diffuse reflectance spectrometer | 12 weeks | |
| Measurement of pigmentation changes induced by the two light sources using Colorimetry | 12 weeks | |
| Measurement of pigmentation changes induced by the two light sources using Cross-Polarized Digital Photography | 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Nicholas Soter | New York University Medical School | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| New York University School of Medicine | New York | New York | 10016 | United States |
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| ID | Term |
|---|---|
| D012871 | Skin Diseases |
| D010859 | Pigmentation Disorders |
| ID | Term |
|---|---|
| D017437 | Skin and Connective Tissue Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Part B: Week 4-Week 12 | Other | The study doctor will perform the same 4 skin assessments used in Part A at each visit to assess potential changes in your skin: Digital Photography
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