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This is a multi-center retrospective observational research study collecting data for participants initiated on docetaxel for the treatment of relapsed non-small cell lung cancer (NSCLC) up to 6 years before start of data collection and who have completed/stopped docetaxel treatment at least 30 days prior to data collection. The primary goal of this study is to describe the percentage of participants with at least one neutropenic sepsis (NS) episode following initiation of treatment with single-agent docetaxel. Data will be collected until end of docetaxel treatment plus an additional 30 days to allow for presentation with toxicity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cohort Docetaxel | Participants initiated on docetaxel for the treatment of relapsed non-small cell lung cancer (NSCLC) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention | Other | No intervention administered in this study |
|
| Measure | Description | Time Frame |
|---|---|---|
| Percentage of Participants Receiving Single-Agent Docetaxel Chemotherapy for Treatment of Relapsed Non-Small Cell Lung Cancer (NSCLC) with an Episode of Neutropenic Sepsis (NS) with an Absolute Neutrophil Count of Less Than 1.0 x 10^9/L | Up to 6 years |
| Measure | Description | Time Frame |
|---|---|---|
| Frequency with which Participants Attend Hospital for Management of Specified Hematological Docetaxel-Related Toxicities, Including Anemia, Thrombocytopenia, Neutropenia, Neutropenic Infection and Pancytopenia | Up to 6 years | |
| Percentage of Participants Receiving Single-Agent Docetaxel Chemotherapy for Treatment of Relapsed Non-Small Cell Lung Cancer (NSCLC) with an Episode of Neutropenic Sepsis (NS) with an Absolute Neutrophil Count of Less Than 0.5 x 10^9/L |
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Inclusion Criteria:
Exclusion Criteria:
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Participants initiated on docetaxel for the treatment of relapsed non-small cell lung cancer (NSCLC)
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| Name | Affiliation | Role |
|---|---|---|
| Clinical Trials | Hoffmann-La Roche | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bristol Haematology and Oncology Centre | Bristol | BS2 8ED | United Kingdom | |||
| Velindre Cancer Centre |
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| Up to 6 years |
| Percentage of Participants with Docetaxel-Related Hematological Toxicities, Including Anemia, Thrombocytopenia, Neutropenia, Neutropenic Infection and Pancytopenia | Up to 6 years |
| Number of Episodes of Neutropenic Sepsis (NS) with an Absolute Neutrophil Count of Less Than 1.0 x 10^9/L | Up to 6 years |
| Number of Episodes of NS with an Absolute Neutrophil Count of Less Than 0.5 x 10^9/L | Up to 6 years |
| Number of Episodes of NS Associated with Death Attributable to NS | Up to 6 years |
| Percentage of Deaths Associated with the Occurrence of an NS Event | Up to 6 years |
| Cardiff |
| CF14 2TL |
| United Kingdom |
| Chelsea & Westminster Hospital | London | SW10 9NH | United Kingdom |
| Maidstone Hospital; Kent Oncology Centre | Maidstone | ME16 0FS | United Kingdom |
| Oxford University Hospitals NHS Trust - Churchill Hospital | Oxford | OX3 7LE | United Kingdom |
| Royal Cornwall Hospital | Truro | TR1 3LQ | United Kingdom |
| Pinderfields General Hospital; Dept of Haematology | Wakefield | WF1 4DG | United Kingdom |
| ID | Term |
|---|---|
| D002289 | Carcinoma, Non-Small-Cell Lung |
| ID | Term |
|---|---|
| D002283 | Carcinoma, Bronchogenic |
| D001984 | Bronchial Neoplasms |
| D008175 | Lung Neoplasms |
| D012142 | Respiratory Tract Neoplasms |
| D013899 | Thoracic Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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