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| Name | Class |
|---|---|
| Peking University | OTHER |
| China Soong Ching Ling Foundation | OTHER |
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The purpose of this study is to investigate the demographic characteristics, clinical features, diagnoses and treatments of AECOPD hospitalized patients in China, and disease prognosis and its economic burden.
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| Measure | Description | Time Frame |
|---|---|---|
| In-hospital mortality | All-cause and cause-specific mortality will be described. | 12 months |
| Readmission | Readmission rate caused by AECOPD within 1 month after discharged from hospital. | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| All-cause and cause-specific mortality | All-cause and cause-specific mortality will be described at different time points (1, 2, 3 years) | 3 years |
| Recurrence of acute exacerbation of COPD | Frequency of AECOPD recurrence will be described during follow-ups, the date of first recurrence after discharge will be analysed. |
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Inclusion Criteria:
≥18 years of age; hospitalized patients with main diagnosis as AECOPD.
Exclusion Criteria:
Patients diagnosed as active pulmonary tuberculosis, or acute left heart failure; Patients participating in clinical trials or intervention studies of drugs.
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AECOPD-IRS plans to enroll 7600 hospitalized patients (≥ 18 years old with main diagnosis as AECOPD). Sample size estimation is based on estimated mortality of AECOPD hospitalized patients (~5%). Study patients will be recruited from 40-60 hospitals across China,each hospital will recruit 152-190 patients. Hospital selection follows a multi-stage sampling strategy.
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 40033752 | Derived | Ren X, He R, Xu Z, Xin Y, Wang Y, Yang T, Wang C. Effects of glucocorticoid administration routes on patients with acute exacerbations of chronic obstructive pulmonary disease in China: A propensity score-matched longitudinal analysis. Chin Med J (Engl). 2026 Mar 5;139(5):689-698. doi: 10.1097/CM9.0000000000003451. Epub 2025 Mar 4. | |
| 38906462 |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
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| 3 years |
| Lung function and quality of life assessment | Lung function will be measured regularly, quality of life will be assessed by questionnaires | 3 years |
| Healthcare costs | Direct costs of hospital stay will be recorded. | 12 months |
| Niu Y, Niu H, Meng X, Zhu Y, Ren X, He R, Wu H, Yu T, Zhang Y, Kan H, Chen R, Yang T, Wang C. Associations Between Air Pollution and the Onset of Acute Exacerbations of COPD: A Time-Stratified Case-Crossover Study in China. Chest. 2024 Nov;166(5):998-1009. doi: 10.1016/j.chest.2024.05.030. Epub 2024 Jun 19. |
| 37855117 | Derived | He R, Wang Y, Ren X, Huang K, Lei J, Niu H, Li W, Dong F, Li B, Yang T, Wang C. Associations of medication regimen complexity with medication adherence and clinical outcomes in patients with chronic obstructive pulmonary disease: a prospective study. Ther Adv Respir Dis. 2023 Jan-Dec;17:17534666231206249. doi: 10.1177/17534666231206249. |
| D020969 |
| Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |