Study of the Involvement of IL-17 / IL-22 Pathway in Bacterial Exacerbations of COPD

Study of the Involvement of IL-17 / IL-22 Pathway in Bacterial Exacerbations of COPD

Chronic obstructive pulmonary disease (COPD) is a worldwide chronic inflammatory disease of the airways linked to environmental exposure. The chronic course of COPD is often interrupted by acute exacerbations which have a major impact on the morbidity and mortality of COPD patients. A bacterial etiology for these exacerbations is common (almost 50%). Moreover, airway bacterial colonization linked to an increased susceptibility is observed in COPD patients. Effective Th17 immune response is needed to develop a good response against bacteria. Thus, this study aims to demonstrate that there is a defective IL-17/ IL-22 response to bacteria in COPD leading to airway bacterial colonization and infection.

Inclusion Criteria:

• Diagnosed COPD according GOLD guidelines
• Current or ex-smoker (at least 10 pack-years)
• Hospitalized for COPD exacerbation

Exclusion Criteria:

• Asthma or Cystic fibrosis
• No other chronic lung disease
• Solid Tumor unhealed or not considered in remission
• Inhaled drug consumption
• Women of childbearing potential without effective contraception
• Pregnant or breastfeeding women
• Incapable of consent
• Lack of social security coverage